Article Text
Abstract
Despite their clearly demonstrated safety and effectiveness, approved vaccines against COVID-19 are commonly mistrusted. Nations should find and implement effective ways to boost vaccine confidence. But the implications for ethical vaccine development are less straightforward than some have assumed. Opponents of COVID-19 vaccine challenge trials, in particular, made speculative or empirically implausible warnings on this matter, some of which, if applied consistently, would have ruled out most COVID-19 vaccine trials and many non-pharmaceutical responses.
- COVID-19
- research ethics
- clinical trials
- public health ethics
- ethics
Data availability statement
No data are available.
This article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
https://bmj.com/coronavirus/usageStatistics from Altmetric.com
Data availability statement
No data are available.
Footnotes
Contributors NE has conceptualised and written this entire essay.
Funding This study was funded by National Science Foundation (Award # 2039320), Open Philanthropy (Award # not applicable).
Competing interests NE serves on the Advisory Board of challenge trial volunteer organisation 1DaySooner (a non-profit promoting human challenge trials in COVID-19), an unpaid position.
Provenance and peer review Not commissioned; externally peer reviewed.
Read the full text or download the PDF:
Other content recommended for you
- COVID-19 controlled human infection studies: worries about local community impact and demands for local engagement
- Vaccine confidence, public understanding and probity: time for a shift in focus?
- Do coronavirus vaccine challenge trials have a distinctive generalisability problem?
- Using social media to build confidence in vaccines: lessons from community engagement and social science research in Africa
- Understanding attitudes and beliefs regarding COVID-19 vaccines among transitional-aged youth with mental health concerns: a youth-led qualitative study
- Acceptance of COVID-19 vaccines in Palestine: a cross-sectional online study
- Public acceptance of COVID-19 vaccines: cross-national evidence on levels and individual-level predictors using observational data
- Correlates of intended COVID-19 vaccine acceptance across time and countries: results from a series of cross-sectional surveys
- Confronting ‘chaos’: a qualitative study assessing public health officials’ perceptions of the factors affecting Tanzania’s COVID-19 vaccine rollout
- Science, healthcare system, and government effectiveness perception and COVID-19 vaccination acceptance and hesitancy in a global sample: an analytical cross-sectional analysis