Autopsy histopathologic cardiac findings in 2 adolescents following the second COVID-19 vaccine dose
JR Gill, R Tashjian… - Archives of pathology & …, 2022 - meridian.allenpress.com
JR Gill, R Tashjian, E Duncanson
Archives of pathology & laboratory medicine, 2022•meridian.allenpress.comContext.—Myocarditis in adolescents has been diagnosed clinically following the
administration of the second dose of an mRNA vaccine for coronavirus disease 2019
(COVID-19). Objective.—To examine the autopsy microscopic cardiac findings in adolescent
deaths that occurred shortly following administration of the second Pfizer-BioNTech COVID-
19 dose to determine if the myocarditis described in these instances has the typical
histopathology of myocarditis. Design.—Clinical and autopsy investigation of 2 teenage …
administration of the second dose of an mRNA vaccine for coronavirus disease 2019
(COVID-19). Objective.—To examine the autopsy microscopic cardiac findings in adolescent
deaths that occurred shortly following administration of the second Pfizer-BioNTech COVID-
19 dose to determine if the myocarditis described in these instances has the typical
histopathology of myocarditis. Design.—Clinical and autopsy investigation of 2 teenage …
Context
Myocarditis in adolescents has been diagnosed clinically following the administration of the second dose of an mRNA vaccine for coronavirus disease 2019 (COVID-19).
Objective
To examine the autopsy microscopic cardiac findings in adolescent deaths that occurred shortly following administration of the second Pfizer-BioNTech COVID-19 dose to determine if the myocarditis described in these instances has the typical histopathology of myocarditis.
Design
Clinical and autopsy investigation of 2 teenage boys who died shortly following administration of the second Pfizer-BioNTech COVID-19 dose.
Results
The microscopic examination revealed features resembling a catecholamine-induced injury, not typical myocarditis pathology.
Conclusions
The myocardial injury seen in these postvaccine hearts is different from typical myocarditis and has an appearance most closely resembling a catecholamine-mediated stress (toxic) cardiomyopathy. Understanding that these instances are different from typical myocarditis and that cytokine storm has a known feedback loop with catecholamines may help guide screening and therapy.
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