Halothane-induced alterations in cellular structure and proliferation of A549 cells
E Stephanova, T Topouzova-Hristova, R Hazarosova… - Tissue and Cell, 2008 - Elsevier
Genotoxicity, cytotoxicity or teratogenicity are among the well-known detrimental effects of
the volatile anaesthetics. The aim of the present work was to study the structural changes,
proliferative activity and the possibility of alveolar A549 cells to recover after in vitro
exposure to halothane at 1.5 and 2.1 mM concentrations. Our data indicated significant
reduction of viability, suppression of mitotic activity more than 60%, and that these
alterations were accompanied by disturbances of nuclear and nucleolar structures. The most …
the volatile anaesthetics. The aim of the present work was to study the structural changes,
proliferative activity and the possibility of alveolar A549 cells to recover after in vitro
exposure to halothane at 1.5 and 2.1 mM concentrations. Our data indicated significant
reduction of viability, suppression of mitotic activity more than 60%, and that these
alterations were accompanied by disturbances of nuclear and nucleolar structures. The most …