[HTML][HTML] Immunological considerations for SARS-CoV-2 human challenge studies
AD Douglas, AVS Hill - Nature Reviews Immunology, 2020 - nature.com
Nature Reviews Immunology, 2020•nature.com
The ethics and practicalities of controlled human infection with SARS-CoV-2 have been
widely discussed. Potential risks are clear. The case in favour hinges upon whether these
risks can be mitigated to an acceptable, very low, level and whether the studies will provide
substantial benefits that could not readily be obtained by other means. Here, we discuss the
immunological considerations relating to each side of this balance.
widely discussed. Potential risks are clear. The case in favour hinges upon whether these
risks can be mitigated to an acceptable, very low, level and whether the studies will provide
substantial benefits that could not readily be obtained by other means. Here, we discuss the
immunological considerations relating to each side of this balance.
The ethics and practicalities of controlled human infection with SARS-CoV-2 have been widely discussed. Potential risks are clear. The case in favour hinges upon whether these risks can be mitigated to an acceptable, very low, level and whether the studies will provide substantial benefits that could not readily be obtained by other means. Here, we discuss the immunological considerations relating to each side of this balance.
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