Background: Recombinant factor VIIa (rFVIIa), a hemostatic agent approved for hemophilia,
is increasingly used for off-label indications. Purpose: To evaluate the benefits and harms of …

Objective To determine whether financial ties to one drug company are associated with
favourable results or conclusions in meta-analyses on antihypertensive drugs. Design …

A published article is the primary means whereby new work is communicated, priority is
established, and academic promotion is determined. Publication depends on trust and …

Background The Diabetes Prevention Program (DPP) lifestyle intervention reduced the
incidence of type 2 diabetes mellitus (DM) among high-risk adults by 58%, with weight loss …

Background: Authorship disputes and abuses have increased in recent years. In response to
a proposal that researcher contributions be specified for readers, The Lancet began …

ContextTo determine the prevalence of honorary and ghost authorship in Cochrane reviews,
how authorship is assigned, and the ways in which authors and Cochrane editorial teams …

Background: Recombinant factor VIIa (rFVIIa) is approved for treatment of bleeding in
patients who have hemophilia with inhibitors but has been applied to a wide range of off …

4. Bruster S, Jarman B, Bosanquet N, Weston D, Erens R, Delbanco TL. National survey of
hospital patients. BMJ. 1994; 309: 1542-1546. 5. Quill TE, Dresser R, Brock DW. The rule of …

ContextTo determine whether journals have improved their disclosure of ethical protections
in clinical trials. MethodsComparison of clinical trials published before and after 1997 (July …

Importance Observational evidence suggests that higher physical activity is associated with
slower kidney function decline; however, to our knowledge, no large trial has evaluated …