User profiles for "author:Spencer Phillips Hey"
Spencer Phillips HeyPrism Analytic Technologies Verified email at prism.bio Cited by 1773 |
Assessment of the clinical benefit of cancer drugs receiving accelerated approval
Importance The US Food and Drug Administration's (FDA's) accelerated approval pathway
allows investigational cancer drugs to be approved by demonstrating a beneficial effect on a …
allows investigational cancer drugs to be approved by demonstrating a beneficial effect on a …
The questionable use of unequal allocation in confirmatory trials
SP Hey, J Kimmelman - Neurology, 2014 - AAN Enterprises
Randomization is the standard means for addressing known and unknown confounders
within the patient population in clinical trials. Although random assignment to treatment arms …
within the patient population in clinical trials. Although random assignment to treatment arms …
A review of pragmatic trials found a high degree of diversity in design and scope, deficiencies in reporting and trial registry data, and poor indexing
Objective We established a large database of trials to serve as a resource for future
methodological and ethical analyses. Here, we use meta-data to describe the broad …
methodological and ethical analyses. Here, we use meta-data to describe the broad …
Are outcome-adaptive allocation trials ethical?
SP Hey, J Kimmelman - Clinical trials, 2015 - journals.sagepub.com
Randomization is firmly established as a cornerstone of clinical trial methodology. Yet, the
ethics of randomization continues to generate controversy. The default, and most efficient …
ethics of randomization continues to generate controversy. The default, and most efficient …
A comparison of response patterns for progression-free survival and overall survival following treatment for cancer with PD-1 inhibitors: a meta-analysis of correlation …
Importance Based on efficacy results from pivotal randomized clinical trials, PD-1
(programmed cell death 1) inhibitors, such as nivolumab and pembrolizumab, have been …
(programmed cell death 1) inhibitors, such as nivolumab and pembrolizumab, have been …
Cluster over individual randomization: are study design choices appropriately justified? Review of a random sample of trials
M Taljaard, CE Goldstein, B Giraudeau… - Clinical …, 2020 - journals.sagepub.com
Background: Novel rationales for randomizing clusters rather than individuals appear to be
emerging from the push for more pragmatic trials, for example, to facilitate trial recruitment …
emerging from the push for more pragmatic trials, for example, to facilitate trial recruitment …
Is the concept of clinical equipoise still relevant to research?
Is the concept of clinical equipoise still relevant to research? | The BMJ Skip to main content
Intended for healthcare professionals Access provided by Google Indexer Subscribe My …
Intended for healthcare professionals Access provided by Google Indexer Subscribe My …
[HTML][HTML] Heterogeneity of antidiabetic treatment effect on the risk of major adverse cardiovascular events in type 2 diabetes: a systematic review and meta-analysis
Background We explored whether clinically relevant baseline characteristics of patients with
type 2 diabetes can modify the effect of glucagon-like peptide-1 receptor agonists (GLP-1 …
type 2 diabetes can modify the effect of glucagon-like peptide-1 receptor agonists (GLP-1 …
[HTML][HTML] Cell and gene therapy trials: are we facing an 'evidence crisis'?
M Abou-El-Enein, SP Hey - EClinicalMedicine, 2019 - thelancet.com
Cell and Gene Therapy Trials: Are We Facing an ‘Evidence Crisis’? - eClinicalMedicine Skip to
Main Content Advertisement EClinicalMedicine This Journal Back Journal Home Online First …
Main Content Advertisement EClinicalMedicine This Journal Back Journal Home Online First …
A systematic review of the food and drug administration's 'exception from informed consent'pathway
In 1996 the Food and Drug Administration (FDA) created an “exception from informed
consent”(EFIC) pathway for trials conducted on people incapacitated by life-threatening …
consent”(EFIC) pathway for trials conducted on people incapacitated by life-threatening …