Pancreatic ductal adenocarcinoma (PDAC), which accounts for more than 90% of all
pancreatic tumours, is a devastating malignancy with an extremely poor prognosis, as …

Gastric cancer is one of the most common cancers and one of the most frequent causes of
cancer-related deaths. The incidence, diagnostic studies, and therapeutic options have …

Colon cancer is one of the leading tumours in the world and it is considered among the big
killers, together with lung, prostate and breast cancer. In the recent years very important …

Purpose Mutations within the KRAS proto-oncogene have predictive value but are of
uncertain prognostic value in the treatment of advanced colorectal cancer. We took …

Purpose Prior reports have indicated that patients with colon cancer who demonstrate high-
level microsatellite instability (MSI-H) or defective DNA mismatch repair (dMMR) have …

Background In phase II trials, irinotecan is active in patients with advanced colorectal
cancer, but the survival and clinical benefit of irinotecan compared with secondline …

Purpose Although it is well-established that fluorouracil-(FU-) based adjuvant therapy
improves survival for patients with resected high-risk colon cancer, the magnitude of …

Background Adjuvant chemotherapy is standard treatment for patients with resected colon
cancer who are at high risk for recurrence, but the efficacy and toxicity of such treatment in …

Background Since 2004, a regimen of 6 months of treatment with oxaliplatin plus a
fluoropyrimidine has been standard adjuvant therapy in patients with stage III colon cancer …

PURPOSE: To study the prognostic value for overall survival of baseline assessment of
functional status, comorbidity, and quality of life (QoL) in elderly patients with advanced non …