Last spring, the US National Institutes of Health (NIH) announced a new policy calling for the
use of both male and female materials—animals, tissues, cells, and cell lines—in preclinical …

The use of preimplantation genetic diagnosis (PGD) has expanded both in number and
scope over the past 2 decades. Initially carried out to avoid the birth of children with severe …

The framing of cystic fibrosis (CF) changed from a strictly genetic disease in the mid-to late-
twentieth century to a genetic/infectious hybrid of sorts by the early twenty-first century …

In 1971, Günter Blobel and David Sabatini proposed a novel and quite speculative
schematic model to describe how proteins might reach the proper cellular location …

Mist tent therapy for cystic fibrosis went through a rise and fall in popularity between the
1950s and 1970s, providing an opportunity to explore the nature of therapeutic change in …

Informed consent for preimplantation genetic diagnosis (PGD) is especially complex
because it includes several procedures, all of which have risks that must be discussed: PGD …

Natural killer (NK) cells express families of receptors that are capable of detecting MHC
class I expression on the surface of cells. CD94/NKG2 family members, which include both …

Müller-Wille examine the history of the concept of the gene over the course of the twentieth
century to better understand how the gene concept has changed in the postgenomic age. In …

This dissertation examines why diagnostic uncertainty persists in medicine and the impact of
such uncertainty on patients and families. Using cystic fibrosis (CF) as a case study, this …