Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term perspective

T Jernberg, P Hasvold, M Henriksson… - European heart …, 2015 - academic.oup.com
Aims Long-term disease progression following myocardial infarction (MI) is not well
understood. We examined the risk of subsequent cardiovascular events in patients …

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques… - Nature, 2014 - nature.com
Cancers have dysfunctional redox regulation resulting in reactive oxygen species
production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized …

[HTML][HTML] Swedish experience-based value sets for EQ-5D health states

K Burström, S Sun, UG Gerdtham, M Henriksson… - Quality of Life …, 2014 - Springer
Abstract Purpose To estimate Swedish experience-based value sets for EQ-5D health states
using general population health survey data. Methods Approximately 45,000 individuals …

Randomized clinical trial of the costs of open and laparoscopic surgery for colonic cancer

M Janson, I Björholt, P Carlsson… - Journal of British …, 2004 - academic.oup.com
Background There has been no randomized clinical trial of the costs of laparoscopic colonic
resection (LCR) compared with those of open colonic resection (OCR) in the treatment of …

Cost-effectiveness of treating acute coronary syndrome patients with ticagrelor for 12 months: results from the PLATO study

E Nikolic, M Janzon, O Hauch, L Wallentin… - European heart …, 2013 - academic.oup.com
Aims The efficacy and safety of ticagrelor vs. clopidogrel in patients with acute coronary
syndromes (ACS) are well documented in the PLATelet inhibition and patient Outcomes trial …

A systematic review of cost-effectiveness models in type 1 diabetes mellitus

M Henriksson, R Jindal, C Sternhufvud… - …, 2016 - Springer
Background Critiques of cost-effectiveness modelling in type 1 diabetes mellitus (T1DM) are
scarce and are often undertaken in combination with type 2 diabetes mellitus (T2DM) …

[HTML][HTML] Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

N Bonagas, NMS Gustafsson, M Henriksson, P Marttila… - Nature cancer, 2022 - nature.com
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/
cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully …

[HTML][HTML] Disease progression modeling for economic evaluation in nonalcoholic fatty liver disease—a systematic review

L Gruneau, M Ekstedt, S Kechagias… - Clinical Gastroenterology …, 2023 - Elsevier
Abstract Background & Aims Globally, 25% of people have Non-Alcoholic Fatty Liver
Disease (NAFLD) and currently there are no approved pharmacological treatments for …

[HTML][HTML] Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

AC Green, P Marttila, N Kiweler, C Chalkiadaki… - Nature …, 2023 - nature.com
Cancer cells fuel their increased need for nucleotide supply by upregulating one-carbon
(1C) metabolism, including the enzymes methylenetetrahydrofolate dehydrogenase …

[HTML][HTML] Experience-based Swedish TTO and VAS value sets for EQ-5D-5L health states

K Burström, FS Teni, UG Gerdtham, R Leidl… - …, 2020 - Springer
Abstract Background and Objective Although value sets for the five-level version of the
generic health-related quality-of-life instrument EQ-5D are emerging, there is still no value …