Benefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson's disease

Z Master, M McLeod, I Mendez - Journal of Medical Ethics, 2007 - jme.bmj.com
Stem cells are likely to be used as an alternate source of biological material for neural
transplantation to treat Parkinson's disease in the not too distant future. Among the several …

First-in-human phase 1 CRISPR gene editing cancer trials: are we ready?

F Baylis, M McLeod - Current gene therapy, 2017 - ingentaconnect.com
A prospective first-in-human Phase 1 CRISPR gene editing trial in the United States for
patients with melanoma, synovial sarcoma, and multiple myeloma offers hope that gene …

Spinal GABAergic transplants attenuate mechanical allodynia in a rat model of neuropathic pain

K Mukhida, I Mendez, M McLeod, N Kobayashi… - Stem …, 2007 - academic.oup.com
Injury to the spinal cord or peripheral nerves can lead to the development of allodynia due to
the loss of inhibitory tone involved in spinal sensory function. The potential of intraspinal …

[HTML][HTML] Survival, differentiation, and migration of bioreactor-expanded human neural precursor cells in a model of Parkinson disease in rats

K Mukhida, BA Baghbaderani, M Hong… - Neurosurgical …, 2008 - thejns.org
Object Fetal tissue transplantation for Parkinson disease (PD) has demonstrated promising
results in experimental and clinical studies. However, the widespread clinical application of …

Transplantation of GABAergic cells derived from bioreactor-expanded human neural precursor cells restores motor and cognitive behavioral deficits in a rodent model …

MC McLeod, NR Kobayashi, A Sen… - Cell …, 2013 - journals.sagepub.com
Huntington's disease (HD) is a neurodegenerative disorder that is characterized by
progressive dementia, choreiform involuntary movements, and emotional deterioration …

The ethics of human embryos and embryonic stem cell research

Z Master, D Laforce, M McLeod… - Journal of Stem …, 2008 - mayoclinic.elsevierpure.com
The science of human embryonic stem (hES) cells holds tremendous promise for the
discovery of revolutionary cellular therapeutic options for the restoration and regeneration of …

[PDF][PDF] Moral and scientific considerations in embryonic stem cell research

Z Master, D Laforce, M McLeod… - Stem Cell …, 2011 - researchgate.net
The science of human embryonic stem (hES) cells holds tremendous promise for the
discovery of revolutionary cellular therapeutic options for the restoration and regeneration of …

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J Riley, W Sweeney, N Boulis, D Yu, GA Silva… - 2008 - thejns.org

[CITATION][C] Enhancement of sensorimotor behavioral recovery in Parkinsonian rats with a multitarget basal ganglia dopaminergic and GABAergic transplantation …

K Mukhida, M Hong, G Miles… - JOURNAL OF …, 2007 - … , 1224 WEST MAIN ST, STE 450 …