[HTML][HTML] Molecular testing for gastrointestinal cancer
With recent advances in molecular diagnostic methods and targeted cancer therapies,
several molecular tests have been recommended for gastric cancer (GC) and colorectal …
several molecular tests have been recommended for gastric cancer (GC) and colorectal …
[HTML][HTML] Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer
Background The immunoscore (IS), an index based on the density of CD3+ and CD8+ tumor-
infiltrating lymphocytes (TILs) in the tumor center (CT) and invasive margin (IM), has gained …
infiltrating lymphocytes (TILs) in the tumor center (CT) and invasive margin (IM), has gained …
[HTML][HTML] PD-L1 testing in gastric cancer by the combined positive score of the 22C3 PharmDx and SP263 assay with clinically relevant cut-offs
Y Park, J Koh, HY Na, Y Kwak, KW Lee… - Cancer Research and …, 2020 - ncbi.nlm.nih.gov
Purpose We provide a comparison between 22C3 pharmDx and SP263 assay, for
evaluating programmed death ligand 1 (PD-L1) expression in advanced gastric cancer (GC) …
evaluating programmed death ligand 1 (PD-L1) expression in advanced gastric cancer (GC) …
Genetic profiles of subcutaneous panniculitis-like T-cell lymphoma and clinicopathological impact of HAVCR2 mutations
J Koh, I Jang, S Mun, C Lee, HJ Cha, YH Oh… - Blood …, 2021 - ashpublications.org
Recent studies identified germline mutations in HAVCR2 (encoding T-cell immunoglobulin
mucin 3) as a genetic factor that predisposes to subcutaneous panniculitis-like T-cell …
mucin 3) as a genetic factor that predisposes to subcutaneous panniculitis-like T-cell …
[HTML][HTML] Clinicopathologic implications of immune classification by PD-L1 expression and CD8-positive tumor-infiltrating lymphocytes in stage II and III gastric cancer …
We co-assessed PD-L1 expression and CD8+ tumor-infiltrating lymphocytes in gastric
cancer (GC), and categorized into 4 microenvironment immune types …
cancer (GC), and categorized into 4 microenvironment immune types …
[HTML][HTML] Longitudinal multi-omics study of palbociclib resistance in HR-positive/HER2-negative metastatic breast cancer
Abstract Background Cyclin-dependent kinase 4/6 inhibitor (CDK4/6) therapy plus
endocrine therapy (ET) is an effective treatment for patients with hormone receptor …
endocrine therapy (ET) is an effective treatment for patients with hormone receptor …
[HTML][HTML] BRAF, PIK3CA, and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal Cancers with Distant Metastasis
Background Anti-EGFR antibody–based treatment is an important therapeutic strategy for
advanced colorectal cancer (CRC); despite this, several mutations—including KRAS, BRAF …
advanced colorectal cancer (CRC); despite this, several mutations—including KRAS, BRAF …
Expression of the immune checkpoint receptors PD-1, LAG3, and TIM3 in the immune context of stage II and III gastric cancer by using single and chromogenic …
Y Park, AN Seo, J Koh, SK Nam, Y Kwak… - …, 2021 - Taylor & Francis
We sought to determine the clinicopathological significance of PD-1, LAG3, and TIM3 in
gastric cancer (GC) by examining their expression and immune context …
gastric cancer (GC) by examining their expression and immune context …
[HTML][HTML] Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer
HJ Hwang, SK Nam, H Park, Y Park, J Koh… - Journal of pathology …, 2020 - ncbi.nlm.nih.gov
Background Recently, molecular classifications of gastric cancer (GC) have been proposed
that include TP53 mutations and their functional activity. We aimed to demonstrate the …
that include TP53 mutations and their functional activity. We aimed to demonstrate the …
Nicotinamide (niacin) supplement increases lipid metabolism and ROS‐induced energy disruption in triple‐negative breast cancer: potential for drug repositioning as …
Metabolic dysregulation is an important hallmark of cancer. Nicotinamide (NAM), a water‐
soluble amide form of niacin (vitamin B3), is currently available as a supplement for …
soluble amide form of niacin (vitamin B3), is currently available as a supplement for …