User profiles for "author:J Briscoe"

James Briscoe

- Verified email at crick.ac.uk - Cited by 26934

Jon P. Briscoe

- Verified email at niu.edu - Cited by 7637

The mechanisms of Hedgehog signalling and its roles in development and disease

J Briscoe, PP Thérond - Nature reviews Molecular cell biology, 2013 - nature.com
The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

Specification of neuronal fates in the ventral neural tube

J Briscoe, J Ericson - Current opinion in neurobiology, 2001 - Elsevier
The generation of distinct classes of neurons at defined positions is a fundamental step in
the development of the vertebrate central nervous system. Recent work has begun to reveal …

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

E Dessaud, AP McMahon, J Briscoe - 2008 - journals.biologists.com
Neuronal subtype specification in the vertebrate neural tube is one of the best-studied
examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a …

[HTML][HTML] Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

…, A Kawakami, V Van Heyningen, TM Jessell, J Briscoe - Cell, 1997 - cell.com
Distinct classes of motor neurons and ventral interneurons are generated by the graded
signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing …

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

J Briscoe, L Sussel, P Serup, D Hartigan-O'Connor… - Nature, 1999 - nature.com
During vertebrate development, the specification of distinct cell types is thought to be
controlled by inductive signals acting at different concentration thresholds. The degree of …

[HTML][HTML] A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

J Briscoe, A Pierani, TM Jessell, J Ericson - Cell, 2000 - cell.com
Distinct classes of neurons are generated at defined positions in the ventral neural tube in
response to a gradient of Sonic Hedgehog (Shh) activity. A set of homeodomain …

Protean and boundaryless careers: An empirical exploration

JP Briscoe, DT Hall, RLF DeMuth - Journal of vocational behavior, 2006 - Elsevier
While the constructs of protean and boundaryless careers have informed career theory for
years, rigorous empirical examinations of these career models have lagged behind. This …

The interplay of boundaryless and protean careers: Combinations and implications

JP Briscoe, DT Hall - Journal of vocational behavior, 2006 - Elsevier
The boundaryless and protean career concepts are compared in this article. It is suggested
that the theories can be more finely delineated to produce more effective theory and …

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and-γ signal transduction

M Müller, J Briscoe, C Laxton, D Guschin, A Ziemiecki… - Nature, 1993 - nature.com
We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely
defective in interferon response. Complementation of this mutant with JAK1 restored the …

Employability during unemployment: Adaptability, career identity and human and social capital

S McArdle, L Waters, JP Briscoe, DTT Hall - Journal of vocational behavior, 2007 - Elsevier
Recently, Fugate et al.[Fugate, M., Kinicki, AJ, & Ashforth, BE (2004). Employability: A
psycho-social construct, its dimensions, and applications. Journal of Vocational Behavior, 65 …