User profiles for "author:Haim Cohen"

Haim Cohen

Biology professor
Verified email at biu.ac.il
Cited by 18441

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

KT Howitz, KJ Bitterman, HY Cohen, DW Lamming… - Nature, 2003 - nature.com
In diverse organisms, calorie restriction slows the pace of ageing and increases maximum
lifespan. In the budding yeast Saccharomyces cerevisia e, calorie restriction extends …

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

A Brunet, LB Sweeney, JF Sturgill, KF Chua, PL Greer… - science, 2004 - science.org
The Sir2 deacetylase modulates organismal life-span in various species. However, the
molecular mechanisms by which Sir2 increases longevity are largely unknown. We show …

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

HY Cohen, C Miller, KJ Bitterman, NR Wall, B Hekking… - science, 2004 - science.org
A major cause of aging is thought to result from the cumulative effects of cell loss over time.
In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we …

The sirtuin SIRT6 regulates lifespan in male mice

Y Kanfi, S Naiman, G Amir, V Peshti, G Zinman… - Nature, 2012 - nature.com
The significant increase in human lifespan during the past century confronts us with great
medical challenges. To meet these challenges, the mechanisms that determine healthy …

[HTML][HTML] Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

KJ Bitterman, RM Anderson, HY Cohen… - Journal of Biological …, 2002 - ASBMB
The Saccharomyces cerevisiae Sir2 protein is an NAD+-dependent histone deacetylase that
plays a critical role in transcriptional silencing, genome stability, and longevity. A human …

SIRT6, a protein with many faces

AA Gertler, HY Cohen - Biogerontology, 2013 - Springer
Sirtuins are NAD+ dependent deacylases enzymes. There are seven mammalian sirtuins,
SIRT1–SIRT7, which are localized to different cellular compartments and are capable of …

[PDF][PDF] Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

HY Cohen, S Lavu, KJ Bitterman, B Hekking… - Molecular cell, 2004 - cell.com
Apoptosis is a key tumor suppression mechanism that can be initiated by activation of the
proapoptotic factor Bax. The Ku70 DNA end-joining protein has recently been shown to …

The complex role of SIRT6 in carcinogenesis

B Lerrer, AA Gertler, HY Cohen - Carcinogenesis, 2016 - academic.oup.com
SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl
transferase and NAD+-dependent deacylase of both acetyl groups and long-chain fatty acyl …

Redox chemistry of nickel complexes in aqueous solutions

I Zilbermann, E Maimon, H Cohen… - Chemical …, 2005 - ACS Publications
Before 1970, information concerning the redox chemistry of nickel in solution in general and
in water in particular was very scarce. A handful of complexes featuring “atypical” oxidation …

SIRT6 protects against pathological damage caused by diet‐induced obesity

Y Kanfi, V Peshti, R Gil, S Naiman, L Nahum… - Aging cell, 2010 - Wiley Online Library
The NAD+‐dependent SIRT6 deacetylase is a therapeutic candidate against the emerging
metabolic syndrome epidemic. SIRT6, whose deficiency in mice results in premature aging …