Negative expectations deriving from the clinical encounter can produce negative outcomes,
known as nocebo effects. Specifically, research on the nocebo effect indicates that …

Despite growing scientific interest in the placebo effect and increasing understanding of
neurobiological mechanisms, theoretical conceptualization of the placebo effect remains …

Importance Adverse events (AEs) after placebo treatment are common in randomized
clinical drug trials. Systematic evidence regarding these nocebo responses in vaccine trials …

Background Placebo treatment can significantly influence subjective symptoms. However, it
is widely believed that response to placebo requires concealment or deception. We tested …

Clinical Trials and Medical Care: Defining the Therapeutic Misconception | PLOS Medicine Skip
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A predominant ethical view holds that physician‐investigators should conduct their research
with therapeutic intent. And since a physician offering a therapy wouldn't prescribe second …

Placebo effects are often considered the effects of an “inert substance,” but that
characterization is misleading. In a broad sense, placebo effects are improvements in …

The Oxford Textbook of Clinical Research Ethics is the first comprehensive and systematic
reference on clinical research ethics. Under the editorship of experts from the US National …

The first placebo-controlled trial was probably conducted in 1931, when sanocrysin was
compared with distilled water for the treatment of tuberculosis. 1 Ever since then, placebo …

Objective To describe the attitudes and behaviours regarding placebo treatments, defined
as a treatment whose benefits derive from positive patient expectations and not from the …