Despite international and national guidelines, poor asthma control remains an issue.
Asthma exacerbations are costly to both the individual, and the healthcare provider …

Background Most randomized trials of treatment for asthma study highly selected patients
under idealized conditions. Methods We conducted two parallel, multicenter, pragmatic trials …

Background Patterns of health-care use and comorbidities present in patients in the period
before diagnosis of chronic obstructive pulmonary disease (COPD) are unknown. We …

OBJECTIVE. Newborn screening for cystic fibrosis remains controversial because improved
pulmonary function has not been established. Studies to date have not accounted for …

Background Newborn screening for cystic fibrosis might not be introduced if implementation
and running costs are perceived as prohibitive. Compared with clinical diagnosis, newborn …

Objectives To determine the clinical and cost effectiveness of a multifactorial fall prevention
programme compared with usual care in long term care homes. Design Multicentre, parallel …

Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder and
a leading cause of dementia. Current treatment fails to modify underlying disease …

Five newly isolated mycobacteriophages–Angelica, CrimD, Adephagia, Anaya, and Pixie–
have similar genomic architectures to mycobacteriophage TM4, a previously characterized …

Bronchial hyperresponsiveness (BHR) is a key feature of asthma and may be measured by
direct methacholine challenge or indirect adenosine monophosphate (AMP) challenge. We …

Background: Intranasal corticosteroids are regarded as the first-line treatment for allergic
rhinitis, but few studies have directly compared their systemic effects. Objective: The purpose …