Measures of utility among studies of genomic medicine for critically ill infants: a systematic review
KP Callahan, R Mueller, J Flibotte… - JAMA Network …, 2022 - jamanetwork.com
Importance Genomic medicine holds promise to revolutionize care for critically ill infants by
tailoring treatments for patients and providing additional prognostic information to families …
tailoring treatments for patients and providing additional prognostic information to families …
US public attitudes toward COVID-19 vaccine mandates
EA Largent, G Persad, S Sangenito… - JAMA network …, 2020 - jamanetwork.com
Ending the coronavirus disease 2019 (COVID-19) pandemic through vaccination will require
sufficient uptake, possibly through mandatory vaccination. At present, certain vaccines are …
sufficient uptake, possibly through mandatory vaccination. At present, certain vaccines are …
FDA drug approval and the ethics of desperation
In justifying the accelerated approval of aducanumab (Aduhelm; Biogen), US Food and Drug
Administration (FDA) officials emphasized that many patients with Alzheimer disease and …
Administration (FDA) officials emphasized that many patients with Alzheimer disease and …
[HTML][HTML] Money, coercion, and undue inducement: a survey of attitudes about payments to research participants
EA Largent, C Grady, FG Miller, A Wertheimer - Irb, 2012 - ncbi.nlm.nih.gov
The practice of offering payment to research participants exhibits a tension between the
aims of investigators to recruit subjects and the aims of IRBs to protect them by determining …
aims of investigators to recruit subjects and the aims of IRBs to protect them by determining …
Access to affordable medicines: obligations of universities and academic medical centers
Over the last decade, the development and approval of remarkably effective therapeutic
interventions, many based on technologies directed at the human genome, have altered the …
interventions, many based on technologies directed at the human genome, have altered the …
[HTML][HTML] Paying research participants: regulatory uncertainty, conceptual confusion, and a path forward
EA Largent, HF Lynch - Yale journal of health policy, law, and …, 2017 - ncbi.nlm.nih.gov
The practice of offering payment to individuals in exchange for their participation in clinical
research is widespread and longstanding. Nevertheless, such payment remains the source …
research is widespread and longstanding. Nevertheless, such payment remains the source …
A framework for ethical payment to research participants
L Gelinas, EA Largent, IG Cohen… - … England Journal of …, 2018 - Mass Medical Soc
Ethical Payment to Research Participants The authors propose a framework for evaluating
the appropriateness of payments to research participants. They distinguish three acceptable …
the appropriateness of payments to research participants. They distinguish three acceptable …
Problems with paying people to be vaccinated against COVID-19
EA Largent, FG Miller - Jama, 2021 - jamanetwork.com
TheUSFoodandDrugAdministrationhasissu…-gency Use Authorization for 2 vaccines for the
preventionofcoronavirusdisease2019 (COVID-19). Thisimpressive scientific achievement …
preventionofcoronavirusdisease2019 (COVID-19). Thisimpressive scientific achievement …
[HTML][HTML] Paying research participants: The outsized influence of “undue influence”
EA Largent, HF Lynch - Irb, 2017 - ncbi.nlm.nih.gov
Offers of payment to research participants, though quite common, persist as a source of
ethical controversy. US regulations governing human subjects research do not specifically …
ethical controversy. US regulations governing human subjects research do not specifically …
Public perspectives on COVID-19 vaccine prioritization
G Persad, EJ Emanuel, S Sangenito… - JAMA network …, 2021 - jamanetwork.com
Importance As COVID-19 vaccine distribution continues, policy makers are struggling to
decide which groups should be prioritized for vaccination. Objective To assess US adults' …
decide which groups should be prioritized for vaccination. Objective To assess US adults' …