Measures of utility among studies of genomic medicine for critically ill infants: a systematic review

KP Callahan, R Mueller, J Flibotte… - JAMA Network …, 2022 - jamanetwork.com
Importance Genomic medicine holds promise to revolutionize care for critically ill infants by
tailoring treatments for patients and providing additional prognostic information to families …

US public attitudes toward COVID-19 vaccine mandates

EA Largent, G Persad, S Sangenito… - JAMA network …, 2020 - jamanetwork.com
Ending the coronavirus disease 2019 (COVID-19) pandemic through vaccination will require
sufficient uptake, possibly through mandatory vaccination. At present, certain vaccines are …

FDA drug approval and the ethics of desperation

EA Largent, A Peterson, HF Lynch - JAMA internal medicine, 2021 - jamanetwork.com
In justifying the accelerated approval of aducanumab (Aduhelm; Biogen), US Food and Drug
Administration (FDA) officials emphasized that many patients with Alzheimer disease and …

[HTML][HTML] Money, coercion, and undue inducement: a survey of attitudes about payments to research participants

EA Largent, C Grady, FG Miller, A Wertheimer - Irb, 2012 - ncbi.nlm.nih.gov
The practice of offering payment to research participants exhibits a tension between the
aims of investigators to recruit subjects and the aims of IRBs to protect them by determining …

Access to affordable medicines: obligations of universities and academic medical centers

S Joffe, RM Conti, JL Contreras, EA Largent, HF Lynch… - Gene Therapy, 2023 - nature.com
Over the last decade, the development and approval of remarkably effective therapeutic
interventions, many based on technologies directed at the human genome, have altered the …

[HTML][HTML] Paying research participants: regulatory uncertainty, conceptual confusion, and a path forward

EA Largent, HF Lynch - Yale journal of health policy, law, and …, 2017 - ncbi.nlm.nih.gov
The practice of offering payment to individuals in exchange for their participation in clinical
research is widespread and longstanding. Nevertheless, such payment remains the source …

A framework for ethical payment to research participants

L Gelinas, EA Largent, IG Cohen… - … England Journal of …, 2018 - Mass Medical Soc
Ethical Payment to Research Participants The authors propose a framework for evaluating
the appropriateness of payments to research participants. They distinguish three acceptable …

Problems with paying people to be vaccinated against COVID-19

EA Largent, FG Miller - Jama, 2021 - jamanetwork.com
TheUSFoodandDrugAdministrationhasissu…-gency Use Authorization for 2 vaccines for the
preventionofcoronavirusdisease2019 (COVID-19). Thisimpressive scientific achievement …

[HTML][HTML] Paying research participants: The outsized influence of “undue influence”

EA Largent, HF Lynch - Irb, 2017 - ncbi.nlm.nih.gov
Offers of payment to research participants, though quite common, persist as a source of
ethical controversy. US regulations governing human subjects research do not specifically …

Public perspectives on COVID-19 vaccine prioritization

G Persad, EJ Emanuel, S Sangenito… - JAMA network …, 2021 - jamanetwork.com
Importance As COVID-19 vaccine distribution continues, policy makers are struggling to
decide which groups should be prioritized for vaccination. Objective To assess US adults' …