▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

The human genome sequence can be thought of as a picture of the human organism.
However, like an impressionist painting, the genome is a very large canvas whose details …

Alternative pre-mRNA splicing has an important role in the control of neuronal gene
expression. Many neuronal proteins are structurally diversified through the differential …

Many metazoan gene transcripts exhibit neuron-specific splicing patterns, but the
developmental control of these splicing events is poorly understood. We show that the …

Two different experimental approaches have provided evidence that both U2 and Ul
snRNPs function in premRNA splicing. When the U2 snRNPs in a nuclear extract are …

The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein
involved in multiple aspects of messenger RNA metabolism, including the repression of …

Recent transcriptome analysis indicates that> 90% of human genes undergo alternative
splicing, underscoring the contribution of differential RNA processing to diverse proteomes …

Understanding the biologic role of N 6-methyladenosine (m6A) RNA modifications in mRNA
requires an understanding of when and where in the life of a pre-mRNA transcript the …

Macrophages respond to inflammatory stimuli by modulating the expression of hundreds of
genes in a defined temporal cascade, with diverse transcriptional and posttranscriptional …

We have purified and cloned a new splicing factor, KSRP. KSRP is a component of a
multiprotein complex that binds specifically to an intronic splicing enhancer element …