Studies of acute myocardial infarction, trauma, and stroke have been translated into
improved outcomes by earlier diagnosis and application of therapy at the most proximal …

Severe sepsis is a medical emergency affecting up to 18 million individuals world wide, with
an annual incidence of 750,000 in North America alone. Mortality ranges between 28-50 …

Background: In 1992, the first consensus definition of severe sepsis was published.
Subsequent epidemiologic estimates were collected using administrative data, but ongoing …

Objective: To test whether the association between initial serum lactate level and mortality in
patients presenting to the emergency department (ED) with severe sepsis is independent of …

Objective: To study the association between time to antibiotic administration and survival in
patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated …

Objectives: We sought to review findings from recent literature on the postresuscitation care
of cardiac arrest patients using therapeutic hypothermia as part of nontrial treatment. Design …

What started as a cluster of patients with a mysterious respiratory illness in Wuhan, China, in
December 2019, was later determined to be coronavirus disease 2019 (COVID-19). The …

Objective: To define a biomarker panel to predict organ dysfunction, shock, and in-hospital
mortality in emergency department (ED) patients with suspected sepsis. Design: Prospective …

BACKGROUND: Comatose survivors of out-of-hospital cardiac arrest (OHCA) have high in-
hospital mortality due to a complex pathophysiology that includes cardiovascular …

STUDY OBJECTIVE: Abnormal (both low and high) central venous saturation (ScvO2) is
associated with increased mortality in emergency department (ED) patients with suspected …