Guidelines around the world require children to provide assent for their participation in most
research studies. Yet, little further guidance is provided on how review committees should …

Emerging data suggest that type 1 diabetes is a more aggressive disease in children than in
adults, with important differences in pathophysiology and clinical course. Therefore, the …

Purpose Recent development of drugs that target specific pathways in tumors has increased
scientific interest in studying drug effects on tumor tissue. As a result, biopsies have become …

Purpose One third of people newly living with HIV/AIDS are adolescents. Research on
adolescent HIV prevention is critical owing to differences between adolescents and adults …

In 2013, researchers announced that a newborn child from Mississippi, USA might have
been functionally cured of HIV by being given combination antiretroviral therapy within hours …

The coronavirus pandemic continues to hinder the ability of businesses to operate at full
capacity. Vaccination offers a path for employees to return to work, and for businesses to …

Work on the therapeutic misconception suggests that investigators should ensure that
potential research subjects understand the fundamental differences between clinical …

In a previous article, I attempted to assess the likely impact of the most prominent versions of
the therapeutic misconception (TM) on research subjects' informed consent. I concluded that …

Genetic research on human biospecimens is increasingly common. However, debate
continues over the level of risk that this research poses to sample donors. Some argue that …

is profoundly disappointing. We write to clarify that research on the use of very early
antiretroviral therapy (ART) in infants born to mothers with HIV is still important. This …