Objective: Benzodiazepines, either alone or added to neuroleptics, have been studied
extensively as treatments for schizophrenia, but no consensus regarding their efficacy has …

A major line of evidence that supports the hypothesis of dopamine overactivity in
schizophrenia is the psychomimetic potential of agents such as amphetamine that stimulate …

Primary depression can be associated with substantial hypercortisolism, thus prompting
some researchers to suggest that depression shares pathophysiologic features with …

A rapidly growing body of preclinical data has implicated the glutamatergic N-methyl-d-
aspartate (NMDA) receptor in memory and other cognitive processes. There is …

The N-methyl-d-aspartate (NMDA) receptor has been implicated in the pathophysiology of
schizophrenia. We administered subanesthetic doses of the NMDA receptor antagonist …

• We performed a longitudinal study of chronic schizophrenic patients who were hospitalized
for research purposes at the National Institute of Mental Health (NIMH) Intramural Program …

• Motor performance and cognitive function were examined in depressed patients and
controls. Increasing severity of depression was strongly associated with decrements in …

Objective.—To evaluate the acute effects of anabolic steroids on mood and behavior in male
normal volunteers. Design.—A 2-week, double-blind (subject and rater), fixed-order …

A comment on this article appears in" Antiglucocorticoid effects of DHEA-S in Alzheimer's
disease." Am J Psychiatry. 1992 Aug; 149 (8): 1125-6. A comment on this article appears in" …

Objective Agents that antagonize the N-methyl-D-aspartic acid (NMDA) receptor, such as
phencyclidine and ketamine, produce an acute psychotic state in normal individuals that …