Human T-lymphotropic virus type 1 (HTLV-1) varies little in sequence compared with human
immunodeficiency virus type 1 (HIV) and it is difficult to detect HTLV-1 mRNA, proteins or …

A highly diverse T-cell receptor (TCR) repertoire is a fundamental property of an effective
immune system, and is associated with efficient control of viral infections and other …

Human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis
(HAM/TSP) is a progressive disease of the CNS that causes weakness or paralysis of the …

In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity
of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope …

Mathematical models, which are based on a firm understanding of biological interactions,
can provide nonintuitive insights into the dynamics of host responses to infectious agents …

Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the
acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking …

Cell contact is required for efficient transmission of human T cell leukemia virus–type 1
(HTLV-I) between cells and between individuals, because naturally infected lymphocytes …

In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we
measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a …

The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and
C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load …

Background Secondary progressive multiple sclerosis, for which no satisfactory treatment
presently exists, accounts for most of the disability in patients with multiple sclerosis …