User profiles for "author:Carl Montague"

Carl Montague

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Verified email at ukzn.ac.za
Cited by 9570

The perils of portliness: causes and consequences of visceral adiposity.

CT Montague, S O'Rahilly - Diabetes, 2000 - Am Diabetes Assoc
Although an individual's total fat mass predicts morbidities such as coronary artery disease
and diabetes, the anatomical distribution of adipose tissue is a strong and independent …

[HTML][HTML] Congenital leptin deficiency is associated with severe early-onset obesity in humans

CT Montague, IS Farooqi, JP Whitehead, MA Soos… - Nature, 1997 - nature.com
The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene
encoding leptin, an adipocyte-specific secreted protein which has profound effects on …

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

RS Jackson, JWM Creemers, S Ohagi… - Nature …, 1997 - nature.com
Human obesity has an inherited component, but in contrast to rodent obesity, precise
genetic defects have yet to be defined1. A mutation of carboxypeptidase E (CPE), an …

Depot-and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution

CT Montague, JB Prins, L Sanders, JE Digby… - Diabetes, 1997 - Am Diabetes Assoc
Obese subjects with excess intra-abdominal fat deposition suffer greater adverse metabolic
consequences than do similarly overweight subjects with a predominantly subcutaneous …

Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.

M Adams, CT Montague, JB Prins… - The Journal of …, 1997 - Am Soc Clin Investig
Activation of peroxisome proliferator-activated receptor (PPAR) gamma, a nuclear receptor
highly expressed in adipocytes, induces the differentiation of murine preadipocyte cell lines …

Depot-related gene expression in human subcutaneous and omental adipocytes.

CT Montague, JB Prins, L Sanders, J Zhang… - Diabetes, 1998 - Am Diabetes Assoc
Human omental adipocytes display a range of biochemical properties that distinguish them
from adipocytes of subcutaneous origin. However, information about site-related gene …

Characterization of the human, mouse and rat PGC1beta (peroxisome-proliferator-activated receptor-gamma co-activator 1beta) gene in vitro and in vivo

A Meirhaeghe, V Crowley, C Lenaghan… - Biochemical …, 2003 - portlandpress.com
PGC1α is a co-activator involved in adaptive thermogenesis, fatty-acid oxidation and
gluconeogenesis. We describe the identification of several isoforms of a new human PGC1α …

Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes

JE Digby, CT Montague, CP Sewter, L Sanders… - Diabetes, 1998 - Am Diabetes Assoc
Thiazolidinediones (TZDs) are a novel class of insulinsensitizing agents used in the
treatment of NIDDM and are potent agonists for the nuclear hormone receptor peroxisome …

Barriers and facilitators to the uptake of voluntary medical male circumcision (VMMC) among adolescent boys in KwaZulu–Natal, South Africa

G George, M Strauss, P Chirawu… - African Journal of …, 2014 - Taylor & Francis
Epidemiological modelling has concluded that if voluntary medical male circumcision
(VMMC) is scaled up in high HIV prevalence settings it would lead to a significant reduction …

[HTML][HTML] Implementation of adolescent-friendly voluntary medical male circumcision using a school based recruitment program in rural KwaZulu-Natal, South Africa

C Montague, N Ngcobo, G Mahlase, J Frohlich… - PloS one, 2014 - journals.plos.org
Background Epidemiological data from South Africa demonstrate that risk of human
immunodeficiency virus (HIV) infection in males increases dramatically after adolescence …