The EB1 family represents a highly conserved group of proteins, present in yeast through
humans, that localize to spindle and cytoplasmic microtubules, especially at their distal tips …

T cell stimulation in the absence of a second, costimulatory signal can lead to anergy or the
induction of cell death. CD28 is a major T cell costimulatory receptor, the coengagement of …

The microbial products cyclosporin A (CsA), FK506 and rapamycin are potent
immunosuppressive agents. The introduction of CsA in the early 1970's significantly …

The immunosuppressive agents cyclosporin A (CsA) and FK 506 bind to distinct families of
intracellular proteins (immunophilins) termed cyclophilins and FK 506-binding proteins …

Proliferation and immunologic function of T lymphocytes are initiated by signals from the
antigen receptor that are inhibited by the immunosuppressant FK506 but not by its structural …

The immunosuppressant rapamycin inhibited proliferation of the H4IIEC hepatoma cell line.
Rapamycin, but not its structural analog FK506, also inhibited the basal and insulin …

The use of social media as a recruitment tool for research with humans is increasing, and
likely to continue to grow. Despite this, to date there has been no specific regulatory …

Background: Although cigarette smoking is known to have detrimental effects on the immune
system, the nature of the immunosuppressive agent or agents is poorly understood …

Differentiating 3T3-L1 cells express an immunophilin early during the adipocyte conversion
program as described in this issue [Yeh, W.-C., Li, T.-K., Bierer, BE & McKnight, SL (1995) …

The immunosuppressants FK506 and rapamycin bind to the same immunophilin, FK506
binding protein (FKBP), and inhibit distinct signal transduction pathways in T lymphocytes. A …