Introduction The intrinsic heterogeneity of clinical septic shock is a major challenge. For
clinical trials, individual patient management, and quality improvement efforts, it is unclear …

A panel of variants with alanine substitutions in the small loop of anthrax toxin protective
antigen domain 4 was created to determine individual amino acid residues critical for …

Anthrax lethal toxin produced by the bacteriumBacillus anthracis is the major cause of death
in animals infected with anthrax. One component of this toxin, lethal factor (LF), inactivates …

Introduction Differentiating between sterile inflammation and bacterial infection in critically ill
patients with fever and other signs of the systemic inflammatory response syndrome (SIRS) …

Background We previously derived and validated a risk model to estimate mortality
probability in children with septic shock (PERSEVERE; PEdiatRic SEpsis biomarkEr Risk …

OBJECTIVES: To describe the characteristics of hospitalized children with severe acute
respiratory syndrome coronavirus 2 in New York City metropolitan area. PATIENTS AND …

A variety of ion channels are regulated by cholesterol, a major lipid component of the
plasma membrane whose excess is associated with multiple pathological conditions …

Background User involvement and recovery are now widely used terms within the mental
health policy, research and practice discourse. However, there is a question mark about the …

Objective: Observed associations between fluid balance and septic shock outcomes are
likely confounded by initial mortality risk. We conducted a risk-stratified analysis of the …

Cardiovascular disorders are the major cause of morbidity & mortality globally as well in
India. In 2008, out of the 57 million deaths globally; around 63%(ie, nearly 30 million deaths) …