[HTML][HTML] The road ahead in genetics and genomics

AL McGuire, S Gabriel, SA Tishkoff, A Wonkam… - Nature Reviews …, 2020 - nature.com
In celebration of the 20th anniversary of Nature Reviews Genetics, we asked 12 leading
researchers to reflect on the key challenges and opportunities faced by the field of genetics …

[HTML][HTML] Advances in therapeutic targeting of cancer stem cells within the tumor microenvironment: an updated review

K Dzobo, DA Senthebane, C Ganz, NE Thomford… - Cells, 2020 - mdpi.com
Despite great strides being achieved in improving cancer patients' outcomes through better
therapies and combinatorial treatment, several hurdles still remain due to therapy …

Importance of including non-European populations in large human genetic studies to enhance precision medicine

D Ju, D Hui, DA Hammond, A Wonkam… - Annual review of …, 2022 - annualreviews.org
One goal of genomic medicine is to uncover an individual's genetic risk for disease, which
generally requires data connecting genotype to phenotype, as done in genome-wide …

[HTML][HTML] Pharmacogenomics implications of using herbal medicinal plants on African populations in health transition

NE Thomford, K Dzobo, D Chopera, A Wonkam… - Pharmaceuticals, 2015 - mdpi.com
The most accessible points of call for most African populations with respect to primary health
care are traditional health systems that include spiritual, religious, and herbal medicine. This …

[HTML][HTML] The role of tumor microenvironment in chemoresistance: 3D extracellular matrices as accomplices

DA Senthebane, T Jonker, A Rowe… - International journal of …, 2018 - mdpi.com
Background: The functional interplay between tumor cells and their adjacent stroma has
been suggested to play crucial roles in the initiation and progression of tumors and the …

[HTML][HTML] The co-inheritance of alpha-thalassemia and sickle cell anemia is associated with better hematological indices and lower consultations rate in Cameroonian …

MB Rumaney, VJ Ngo Bitoungui, AA Vorster… - PloS one, 2014 - journals.plos.org
Background Co-inheritance of α-thalassemia was reported to be associated with a delayed
age of disease onset among Cameroonian Sickle Cell Anemia (SCA) patients. The present …

[HTML][HTML] Association of Variants at BCL11A and HBS1L-MYB with Hemoglobin F and Hospitalization Rates among Sickle Cell Patients in Cameroon

A Wonkam, VJ Ngo Bitoungui, AA Vorster, R Ramesar… - PloS one, 2014 - journals.plos.org
Background Genetic variation at loci influencing adult levels of HbF have been shown to
modify the clinical course of sickle cell disease (SCD). Data on this important aspect of SCD …

Sequence three million genomes across Africa

A Wonkam - 2021 - nature.com
Two decades after the completion of the Human Genome Project (HGP), there is still much to
do to ensure that genomics works for the global public good. The focus on populations from …

A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease

GD Pule, S Mowla, N Novitzky… - Expert review of …, 2015 - Taylor & Francis
Aim: To report on molecular mechanisms of fetal hemoglobin (HbF) induction by
hydroxyurea (HU) for the treatment of sickle cell disease. Study Design: Systematic review …

Noonan syndrome in diverse populations

P Kruszka, AR Porras, YA Addissie… - American Journal of …, 2017 - Wiley Online Library
Noonan syndrome (NS) is a common genetic syndrome associated with gain of function
variants in genes in the Ras/MAPK pathway. The phenotype of NS has been well …