The evolution of mycobacterial pathogenicity: clues from comparative genomics
Comparative genomics, and related technologies, are helping to unravel the molecular
basis of the pathogenesis, host range, evolution and phenotypic differences of the slow …
basis of the pathogenesis, host range, evolution and phenotypic differences of the slow …
Comparative genomics of the mycobacteria
The genus mycobacteria includes two important human pathogens Mycobacterium
tuberculosis and Mycobacterium lepra. The former is reputed to have the highest annual …
tuberculosis and Mycobacterium lepra. The former is reputed to have the highest annual …
A new evolutionary scenario for the Mycobacterium tuberculosis complex
The distribution of 20 variable regions resulting from insertion-deletion events in the
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of …
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of …
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti
Although large human populations have been safely immunized against tuberculosis with
two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the …
two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the …
[HTML][HTML] The diarylquinoline TMC207 for multidrug-resistant tuberculosis
Background The diarylquinoline TMC207 offers a new mechanism of antituberculosis action
by inhibiting mycobacterial ATP synthase. TMC207 potently inhibits drug-sensitive and drug …
by inhibiting mycobacterial ATP synthase. TMC207 potently inhibits drug-sensitive and drug …
[HTML][HTML] Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
The live tuberculosis vaccines Mycobacterium bovis BCG (bacille Calmette-Guérin) and
Mycobacterium microti both lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early …
Mycobacterium microti both lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early …
[HTML][HTML] Multidrug-resistant tuberculosis and culture conversion with bedaquiline
Background Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial
ATP synthase, has been associated with accelerated sputum-culture conversion in patients …
ATP synthase, has been associated with accelerated sputum-culture conversion in patients …
Transmission of drug-resistant tuberculosis in HIV-endemic settings
The emergence and expansion of the multidrug-resistant tuberculosis epidemic is a threat to
the global control of tuberculosis. Multidrug-resistant tuberculosis is the result of the …
the global control of tuberculosis. Multidrug-resistant tuberculosis is the result of the …
Bedaquiline in the treatment of multidrug-and extensively drug-resistant tuberculosis
Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant
tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial …
tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial …
Effect of katG Mutations on the Virulence of Mycobacterium tuberculosis and the Implication for Transmission in Humans
The usefulness of isoniazid (INH), a key component of short-course chemotherapy of
tuberculosis, is threatened by the emergence of drug-resistant strains of Mycobacterium …
tuberculosis, is threatened by the emergence of drug-resistant strains of Mycobacterium …