The evolution of mycobacterial pathogenicity: clues from comparative genomics

R Brosch, AS Pym, SV Gordon, ST Cole - Trends in microbiology, 2001 - cell.com
Comparative genomics, and related technologies, are helping to unravel the molecular
basis of the pathogenesis, host range, evolution and phenotypic differences of the slow …

Comparative genomics of the mycobacteria

R Brosch, SV Gordon, A Pym, K Eiglmeier… - International journal of …, 2000 - Elsevier
The genus mycobacteria includes two important human pathogens Mycobacterium
tuberculosis and Mycobacterium lepra. The former is reputed to have the highest annual …

A new evolutionary scenario for the Mycobacterium tuberculosis complex

R Brosch, SV Gordon, M Marmiesse… - Proceedings of the …, 2002 - National Acad Sciences
The distribution of 20 variable regions resulting from insertion-deletion events in the
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of …

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti

AS Pym, P Brodin, R Brosch, M Huerre… - Molecular …, 2002 - Wiley Online Library
Although large human populations have been safely immunized against tuberculosis with
two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the …

[HTML][HTML] The diarylquinoline TMC207 for multidrug-resistant tuberculosis

AH Diacon, A Pym, M Grobusch… - … England Journal of …, 2009 - Mass Medical Soc
Background The diarylquinoline TMC207 offers a new mechanism of antituberculosis action
by inhibiting mycobacterial ATP synthase. TMC207 potently inhibits drug-sensitive and drug …

[HTML][HTML] Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

AS Pym, P Brodin, L Majlessi, R Brosch, C Demangel… - Nature medicine, 2003 - nature.com
The live tuberculosis vaccines Mycobacterium bovis BCG (bacille Calmette-Guérin) and
Mycobacterium microti both lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early …

[HTML][HTML] Multidrug-resistant tuberculosis and culture conversion with bedaquiline

AH Diacon, A Pym, MP Grobusch… - … England Journal of …, 2014 - Mass Medical Soc
Background Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial
ATP synthase, has been associated with accelerated sputum-culture conversion in patients …

Transmission of drug-resistant tuberculosis in HIV-endemic settings

PY Khan, TA Yates, M Osman, RM Warren… - The Lancet Infectious …, 2019 - thelancet.com
The emergence and expansion of the multidrug-resistant tuberculosis epidemic is a threat to
the global control of tuberculosis. Multidrug-resistant tuberculosis is the result of the …

Bedaquiline in the treatment of multidrug-and extensively drug-resistant tuberculosis

AS Pym, AH Diacon, SJ Tang… - European …, 2016 - Eur Respiratory Soc
Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant
tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial …

Effect of katG Mutations on the Virulence of Mycobacterium tuberculosis and the Implication for Transmission in Humans

AS Pym, B Saint-Joanis, ST Cole - Infection and immunity, 2002 - Am Soc Microbiol
The usefulness of isoniazid (INH), a key component of short-course chemotherapy of
tuberculosis, is threatened by the emergence of drug-resistant strains of Mycobacterium …