State of play in amyotrophic lateral sclerosis genetics
Considerable progress has been made in unraveling the genetic etiology of amyotrophic
lateral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the …
lateral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the …
Crime, fear of crime, environment, and mental health and wellbeing: mapping review of theories and causal pathways
This paper presents the findings from a review of the theoretical and empirical literature on
the links between crime and fear of crime, the social and built environment, and health and …
the links between crime and fear of crime, the social and built environment, and health and …
[HTML][HTML] The complex genetic architecture of Alzheimer's disease: novel insights and future directions
SJ Andrews, AE Renton, B Fulton-Howard… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …
disorder and the most common form of dementia. AD is highly heritable, with heritability …
[PDF][PDF] A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD)
locus contains one of the last major unidentified autosomal-dominant genes underlying …
locus contains one of the last major unidentified autosomal-dominant genes underlying …
[HTML][HTML] Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
E Majounie, AE Renton, K Mok, EGP Dopper… - The Lancet …, 2012 - thelancet.com
Background We aimed to accurately estimate the frequency of a hexanucleotide repeat
expansion in C9orf72 that has been associated with a large proportion of cases of …
expansion in C9orf72 that has been associated with a large proportion of cases of …
[PDF][PDF] Genome-wide analyses identify KIF5A as a novel ALS gene
To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 …
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 …
Immunological events in regressing genital warts
N Coleman, HDL Birley, AM Renton… - American journal of …, 1994 - academic.oup.com
Little is known of the< in vivo role of the immune system in controlling human papillomavirus
infection in the genital tract. The authors have studied 125 closely monitored patients with …
infection in the genital tract. The authors have studied 125 closely monitored patients with …
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis
MATR3 is an RNA-and DNA-binding protein that interacts with TDP-43, a disease protein
linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Using exome …
linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Using exome …
Comorbidity of substance misuse and mental illness in community mental health and substance misuse services
…, P Madden, V Charles, G Stimson, A Renton… - The British Journal of …, 2003 - cambridge.org
BackgroundImproved management of mental illness and substance misuse comorbidity is a
National Health Service priority, but little is known about its prevalence and current …
National Health Service priority, but little is known about its prevalence and current …
PINK1 cleavage at position A103 by the mitochondrial protease PARL
E Deas, H Plun-Favreau, S Gandhi… - Human molecular …, 2011 - academic.oup.com
Mutations in PTEN-induced kinase 1 (PINK1) cause early onset autosomal recessive
Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a neuroprotective …
Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a neuroprotective …