The mitotic checkpoint is a major cell cycle control mechanism that guards against
chromosome missegregation and the subsequent production of aneuploid daughter cells …

Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Most solid human tumours are aneuploid, that is, they contain an abnormal number of
chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress …

A major challenge for human genetics is to identify new causes of mental retardation, which,
although present in about 3% of individuals, is unexplained in more than half of all cases …

Background: Despite numerous reports of changes in satiety, food preference, and eating
habits in patients with frontotemporal dementia, there have been few systematic studies …

E ditor—Prader-Willi syndrome (PWS) is a genetically determined disorder in which the
absence of expression of one or more maternally imprinted gene (s) in the chromosomal …

Theories of incentive motivation attempt to capture the way in which objects and events in
the world can acquire high motivational value and drive behavior, even in the absence of a …

The medical findings from a population-based study of Prader-Willi syndrome (PWS) are
discussed (in which birth incidence of PWS was estimated at 1: 22000 and death rate at over …

Background Alzheimer's disease and its complications are the leading cause of death in
adults with Down syndrome. Studies have assessed Alzheimer's disease in individuals with …

BackgroundThe reported prevalence rates of dementia in people with Down's syndrome
have varied considerably across studies. The aim of this study was to investigate the extent …