Emergency Ebola response: a new approach to the rapid design and development of vaccines against emerging diseases

Lancet Infect Dis. 2015 Mar;15(3):356-9. doi: 10.1016/S1473-3099(14)71071-0. Epub 2015 Jan 14.

Abstract

The epidemic of Ebola virus disease has spread at an alarming rate despite containment efforts. As a result, unprecedented large-scale international response efforts have been made in an attempt to gain control of the outbreak and reduce transmission. Several international consortia have been formed in a remarkable worldwide collaborative effort to expedite trials of two candidate Ebola virus vaccines: cAd3-EBOZ and rVSV-EBOV. In parallel, both vaccines are being manufactured in large amounts to enable future rapid deployment for management of the crisis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Clinical Trials as Topic
  • Disease Outbreaks*
  • Ebola Vaccines / immunology*
  • Ebola Vaccines / isolation & purification*
  • Ebolavirus / immunology*
  • Ebolavirus / isolation & purification
  • Hemorrhagic Fever, Ebola / epidemiology*
  • Hemorrhagic Fever, Ebola / prevention & control*
  • Humans
  • International Cooperation

Substances

  • Ebola Vaccines