Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras

Tamir Rashid; Toshihiro Kobayashi; Hiromitsu Nakauchi

doi:10.1016/j.stem.2014.09.013

Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras

Cell Stem Cell. 2014 Oct 2;15(4):406-409. doi: 10.1016/j.stem.2014.09.013.

Authors

Tamir Rashid¹, Toshihiro Kobayashi², Hiromitsu Nakauchi³

Affiliations

¹ Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Centre for Stem Cells and Regenerative Medicine and Institute for Liver Studies, Kings College London, SE1 9RT, UK.
² Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.
³ Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-0071, Japan; Japan Science Technology Agency, ERATO, Nakauchi Stem Cell and Organ Regeneration Project, Tokyo 108-8639, Japan. Electronic address: nakauchi@stanford.edu.

PMID: 25280216
DOI: 10.1016/j.stem.2014.09.013

Abstract

While cell therapies hold great potential for treating many conditions, their utility for treating patients that require whole organ replacement is unclear. To address this challenge, we propose using genetically engineered "organ niches" in large animals to generate human organs from pluripotent stem cells and discuss the hurdles facing such strategies.

Publication types

Review

MeSH terms

Animals
Blastocyst / cytology
Chimera*
Humans
Organ Specificity*
Organogenesis*
Pluripotent Stem Cells / cytology*
Pluripotent Stem Cells / transplantation
Stem Cell Transplantation / adverse effects
Stem Cell Transplantation / ethics

Grants and funding

MR/L006537/1/MRC_/Medical Research Council/United Kingdom