Abstract
In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.
Copyright (c) 2006 S. Karger AG, Basel.
Publication types
-
Meta-Analysis
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Brain Injuries / psychology
-
Brain Injuries / therapy*
-
Caregivers / psychology
-
Caregivers / statistics & numerical data
-
Caregivers / trends
-
Child
-
Clinical Protocols / standards
-
Clinical Trials as Topic / ethics
-
Clinical Trials as Topic / standards*
-
Clinical Trials as Topic / trends*
-
Family / psychology
-
Humans
-
Informed Consent / psychology
-
Informed Consent / standards
-
Outcome Assessment, Health Care / standards
-
Outcome Assessment, Health Care / trends
-
Patient Selection / ethics
-
Pediatrics / ethics
-
Pediatrics / standards*
-
Pediatrics / trends*
-
Practice Guidelines as Topic / standards*
-
Research Support as Topic / statistics & numerical data
-
Research Support as Topic / trends