Abstract
Several interesting biological questions arise when thinking about the heterogeneous presentation of neuroblastoma, especially with regard to the molecular differences between very low- and high-risk disease. Why do some metastatic tumours spontaneously differentiate or regress entirely? Does the presence of disseminated disease always indicate metastases, or might some cases be better considered as multifocal disease?
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
Genome Medicine Open Access 10 February 2017
-
Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells
Scientific Reports Open Access 09 June 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Cheung, N.-K. V. & Dyer, M. A. Neuroblastoma: developmental biology, cancer genomics and immunotherapy. Nature Rev. Cancer 13, 397–411 (2013).
Cohn, S. L. et al. The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J. Clin. Oncol. 27, 289–297 (2009).
Pugh, T. J. et al. The genetic landscape of high-risk neuroblastoma. Nature Genet. 45, 279–284 (2013).
Molenaar, J. J. et al. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes. Nature 483, 589–593 (2012).
Sausen, M. et al. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nature Genet. 45, 12–17 (2013).
Nakagawara, A. et al. Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. N. Engl. J. Med. 328, 847–854 (1993).
D'Angio, G. J., Evans, A. E. & Koop, C. E. Special pattern of widespread neuroblastoma with a favourable prognosis. Lancet 1, 1046–1049 (1971).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Diede, S. Spontaneous regression of metastatic cancer: learning from neuroblastoma. Nat Rev Cancer 14, 71–72 (2014). https://doi.org/10.1038/nrc3656
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrc3656
This article is cited by
-
Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma
Nature Medicine (2018)
-
Spontaneous regression of neuroblastoma
Cell and Tissue Research (2018)
-
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
Genome Medicine (2017)
-
Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells
Scientific Reports (2015)
-
Mechanisms of neuroblastoma regression
Nature Reviews Clinical Oncology (2014)