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Emerging ethical issues in neuroscience

There is growing public awareness of the ethical issues raised by progress in many areas of neuroscience. This commentary reviews the issues, which are triaged in terms of their novelty and their imminence, with an exploration of the relevant ethical principles in each case.

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References

  1. Blank, R.H. Brain Policy: How the New Neuroscience Will Change Our Lives and Our Politics (Georgetown Univ. Press, Washington, DC, 1999).

    Google Scholar 

  2. Fukuyama, F. Our Posthuman Future (Farrar, Straus & Giroux, New York, 2002).

    Google Scholar 

  3. Shastry, B. On the functions of lithium: the mood stabilizer. Bioessays 19, 199–200 (1997).

    Article  CAS  Google Scholar 

  4. Kramer, P.D. Listening to Prozac (Penguin, New York, 1993).

    Google Scholar 

  5. Flett, G.L., Vrendenburg, K. & Krames, L. The continuity of depression in clinical and nonclinical samples. Psychol. Bull. 121, 395–416 (1997).

    Article  CAS  Google Scholar 

  6. Redmond, G. Mood disorders in the female patient. Int. J. Fertility Women's Med. 42, 67–72 (1997).

    CAS  Google Scholar 

  7. Berman, R.M., Belanoff, J.K., Charney, D.S. & Schatzberg, A.F. in Neurobiology of Mental Illness (eds. Charney, D. S., Nestler, E. J. & Bunney, B. S.) 419–432 (Oxford University Press, New York, 1999).

    Google Scholar 

  8. Knutson, B. et al. Selective alteration of personality and social behavior by serotonergic intervention. Am. J. Psychiatry 155, 373–379 (1998).

    Article  CAS  Google Scholar 

  9. Tse, W.S. & Bond, A.J. Serotonergic intervention affects both social dominance and affiliative behaviour. Psychopharmacology 161, 324–330 (2002).

    Article  CAS  Google Scholar 

  10. Elliott, R. et al. Effects of methylphenidate on spatial working memory and planning in healthy young adults. Psychopharmacology 131, 196–206 (1997).

    Article  CAS  Google Scholar 

  11. Diller, L.H. The run on Ritalin: Attention deficit disorder and stimulant treatment in the 1990s. Hastings Center Report 26, 12–14 (1996).

    Article  CAS  Google Scholar 

  12. Babcock, Q. & Byrne, T. Student perceptions of methylphenidate abuse at a public liberal arts college. J. Am. College Health 49, 143–5 (2000).

    Article  CAS  Google Scholar 

  13. Anderson, J. The Adaptive Characteristics of Thought (Erlbaum, Hillsdale, New Jersey, 1990).

  14. Luria, A.R. The Mind of a Mnemonist (Harvard Univ. Press, Cambridge, Massachusetts, 1968).

    Google Scholar 

  15. McClelland, J.L., McNaughton, B.L. & O'Reilly, R.C. Why there are complementary learning systems in the hippocampus and neocortex: Insights from the successes and failures of connectionist models of learning and memory. Psychol. Rev. 102, 419–457 (1995).

    Article  Google Scholar 

  16. Craik, F.I.M. & Salthouse, T.A. The Handbook of Aging and Cognition (Erlbaum, Hillsdale, New Jersey, 1992).

    Google Scholar 

  17. Solomon, P., Adams, F., Silver, A., Zimmer, J. & DeVeaux, R. Ginkgo for memory enhancement: a randomized controlled trial. JAMA 288, 835–840 (2002).

    Article  Google Scholar 

  18. Ingvar, M. et al. Enhancement by an ampakine of memory encoding in humans. Exp. Neurol. 146, 553–559 (1997).

    Article  CAS  Google Scholar 

  19. Lagarde, D., Batejat, D., Van Beers, P., Sarafian, D. & Pradella, S. Interest of modafinil, a new psychostimulant, during a sixty-hour sleep deprivation experiment. Fund. Clin. Pharmacol. 9, 1–9 (1995).

    Article  Google Scholar 

  20. Caldwell, J., Caldwell, J., Smythe, N. & Hall, K. A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study. Psychopharmacology 150, 272–282 (2000).

    Article  CAS  Google Scholar 

  21. Campbell, M.L. & Mathys, M.L. Pharmacologic options for the treatment of obesity. Am. J. Health System Pharmacol. 58, 1301–1308 (2001).

    Article  CAS  Google Scholar 

  22. Armstrong, K., Schwartz, J. & Asch, D. Direct sale of sildenafil (Viagra) to consumers over the internet. New Engl. J. Med. 341, 1389–1392 (1999).

    Article  CAS  Google Scholar 

  23. Parens, E. Enhancing Human Traits: Ethical and Social Implications (Georgetown Univ. Press, Washington, DC, 1998).

    Google Scholar 

  24. Coccaro, E.F., Kavoussi, R.J. & Hauger, R.L. Serotonin function and antiaggressive responsive to fluoxetine: a pilot study. Biol. Psychiatry 42, 546–552 (1997).

    Article  CAS  Google Scholar 

  25. Cherek, D.R., Lane, S.D., Pietras, C.J. & Steinberg, J.L. Effects of chronic paroxetine administration on measures of aggressive and impulsive responses of adult males with a history of conduct disorder. Psychopharmacology 159, 266–274 (2002).

    Article  CAS  Google Scholar 

  26. Manuck, S.B. et al. Aggression, impulsivity, and central nervous system seretonergic responsivity in a nonpatient sample. Neuropsychopharmacology 19, 287–299 (1998).

    Article  CAS  Google Scholar 

  27. Walsh, M.-T. & Dinan, T.G. Selective serotonin reuptake inhibitors and violence: a review of the available evidence. Acta Psychiatry Scand. 104, 84–91 (2001).

    Article  CAS  Google Scholar 

  28. Coccaro, E.F. & Kavoussi, R.J. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch. Gen. Psychiatry 54, 1081–1088 (1997).

    Article  CAS  Google Scholar 

  29. Salzman, C. et al. Effect of fluoxetine on anger in symptomatic volunteers with borderline personality disorder. J. Clin. Psychopharmacol. 15, 23–29 (1995).

    Article  CAS  Google Scholar 

  30. Grossman, L.S., Martis, B. & Fichtner, C.G. Are sex offenders treatable? A research overview. Psychiatric Services 50, 349–361 (1999).

    Article  CAS  Google Scholar 

  31. Diagnostic and Statistical Manual of Mental Disorders IV-R (American Psychiatric Assoc., Washington, DC, 1994).

  32. Morse, S.J. Hooked on hype: addiction and responsibility. Law Philos. 19, 3–49, (2000).

    Google Scholar 

  33. Dougherty, D.D et al. Dopamine transporter density in patients with attention deficit hyperacivity disorder. Lancet 354, 2132–2133 (1999).

    Article  CAS  Google Scholar 

  34. Childress, A.R. et al. Limbic activation during cue-induced cocaine craving. Am. J. Psychiatry 156, 11–18 (1999).

    Article  CAS  Google Scholar 

  35. Garavan, H. et al. Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. Am. J. Psychiatry 157, 1789–1798 (2000).

    Article  CAS  Google Scholar 

  36. Beauregard M., Levesque J., & Bourgouin P. Neural correlates of conscious self-regulation of emotion. J. Neurosci. 21, 1–6 (2001).

    Article  Google Scholar 

  37. Canli, T. & Amin, Z. Neuroimaging of emotion and personality: Scientific evidence and ethical considerations. Brain Cogn. (in press).

  38. Hart, A., Whalen, P., McInerney, S., Fischer, H. & Rauch, S. Differential response in the human amygdala to racial outgroup versus ingroup face stimuli. Neuroreport 11, 2351–2355 (2000).

    Article  CAS  Google Scholar 

  39. Phelps, E. et al. Performance on indirect measures of race evaluation predicts amygdala activation. J. Cogn. Neurosci. 12, 729–738 (2000).

    Article  CAS  Google Scholar 

  40. Langleben, D.D. et al. Brain activity during simulated deception: an event-related functional magnetic resonance study. Neuroimage 15, 727–732 (2002).

    Article  CAS  Google Scholar 

  41. Truog, R.D. Is it time to abandon brain death? Hastings Center Report 27, 29–37 (1997).

    Article  CAS  Google Scholar 

  42. Churchland, P. The Engine of Reason, the Seat of the Soul: A Philosophical Journey into the Brain (MIT Press, Cambridge, Massachusettts, 1995).

    Google Scholar 

  43. Capron, A.M. Ethical and human rights issues in research on mental disorders that may affect decision-making capacity. New Engl. Jl Med. 340, 1430–1434 (1999).

    Article  CAS  Google Scholar 

  44. Valenstein, E.S. Great and Desperate Cures: The Rise and Decline of Psychosurgery and Other Radical Treatments for Mental Illness (Basic, New York, 1986).

    Google Scholar 

  45. Mahli, G.S. & Sachdev, P. Novel physical treatments for the management of neuropsychiatric disorders. J. Psychosom. Res. 53, 709–719 (2002).

    Article  Google Scholar 

  46. Ovsview, F. & Frim, D.M. Neurosurgery for psychiatric disorders. J. Neurol. Neurosurg. Psychiatry 63, 701–705 (1997).

    Article  Google Scholar 

  47. George, M., Wasserman, E. & Post, R. Transcranial magnetic stimulation: A neuropsychiatric tool for the 21st century. J. Neuropsychiatry Clin. Neurosci. 8, 373–382 (1996).

    Article  CAS  Google Scholar 

  48. Cabeza, R., Rao, S.M., Wagner, A.D., Mayer, A.R. & Schacter, D.L. Can medial temporal regions distinguish true from false? Proc. Natl. Acad. Sci. USA 98, 4805–4810 (2001).

    Article  CAS  Google Scholar 

  49. Raine, A. et al. Reduced prefrontal and increased subcortical brain functioning assessed using positron emission tomography in predatory and affective murderers. Behav. Sci. Law 16, 319–332 (1998).

    Article  CAS  Google Scholar 

  50. Greene, J. et al. An fMRI investigation of emotional engagement in moral judgement. Science 293, 2105–2108 (2001).

    Article  CAS  Google Scholar 

  51. McCabe, K., Houser, D., Ryan, L., Smith, V. & Trouard, T. A functional imagng study of cooperation in two-person reciprocal exchange. Proc. Natl. Acad. Sci. USA 98, 11832–11835 (2001)

    Article  CAS  Google Scholar 

  52. O'Craven, K.M. & Kanwisher, N. Mental imagery of faces and places activates corresponding stimulus-specific brain regions. J. Cogn. Neurosci. 12, 1013–1023 (2000).

    Article  CAS  Google Scholar 

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Farah, M. Emerging ethical issues in neuroscience. Nat Neurosci 5, 1123–1129 (2002). https://doi.org/10.1038/nn1102-1123

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