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Stem cells

How to make eggs and sperm

Embryonic stem cells can develop into many specialized cell types in culture dishes. It now seems that they can also generate primordial germ cells, which then go on to form sperm and eggs.

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Figure 1: Germ cells from stem cells.
Figure 2: A possible use for eggs derived from ES cells — nuclear transplantation.

References

  1. Geijsen, N. et al. Nature 427, 148–154 (2004).

    Article  ADS  CAS  Google Scholar 

  2. Toyooka, Y., Tsunekawa, N., Akasu, R. & Noce, T. Proc. Natl Acad. Sci. USA 100, 11457–11462 (2003).

    Article  ADS  CAS  Google Scholar 

  3. Hübner, K. et al. Science 300, 1251–1256 (2003).

    Article  ADS  Google Scholar 

  4. Smith, A. G. Annu. Rev. Cell. Dev. Biol. 17, 435–462 (2001).

    Article  CAS  Google Scholar 

  5. Matzuk, M. M., Burns, K. H., Viveiros, M. M. & Eppig, J. J. Science 296, 2178–2180 (2002).

    Article  ADS  CAS  Google Scholar 

  6. Saunders, P. T. Reproduction 61 (Suppl.), 91–101 (2003).

    CAS  PubMed  Google Scholar 

  7. Hunt, P. A. & Hassold, T. J. Science 296, 2181–2183 (2002).

    Article  ADS  CAS  Google Scholar 

  8. Surani, M. A. Nature 414, 122–128 (2001).

    Article  ADS  CAS  Google Scholar 

  9. Saitou, M., Barton, S. C. & Surani, M. A. Nature 418, 293–300 (2002).

    Article  ADS  CAS  Google Scholar 

  10. Nature 422, 787 (2003).

Download references

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Surani, M. How to make eggs and sperm. Nature 427, 106–107 (2004). https://doi.org/10.1038/427106a

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