Trends in Microbiology
Science & SocietyFraming expectations in early HIV cure research
Section snippets
Acknowledgments
The authors would also like to thank the Fondation Brocher. This work was supported by U19 AI096113 (Collaboratory of AIDS Researchers for Eradication), P30AI50410, and R01A108366 from the National Institutes of Health.
References (12)
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
Blood
(2011)Depletion of latent HIV-1 infection in vivo: a proof-of-concept study
Lancet
(2005)The time is now: moving toward virus-specific T cells after allogeneic hematopoietic stem cell transplantation as the standard of care
Cytotherapy
(2014)The therapeutic misconception: informed consent in psychiatric research
Int. J. Law Psychiatry
(1982)Nucleosides. V. The monomesylates of 1-(2′-deoxy-beta-Dlyxofuranosyl)thymidine
J. Org. Chem.
(1964)Final Report
(1995)
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The words we die by
2024, Social Science and MedicineRe-examining the HIV ‘functional cure’ oxymoron: Time for precise terminology?
2020, Journal of Virus EradicationCitation Excerpt :We call for closer attention to the language used to describe HIV cure-related research, and for continued, significant, and strategic engagement to ensure acceptable and accurate terminology among key stakeholders, including researchers, health care providers, and PLWHIV. A number of articles have scrutinized the language used to describe HIV cure-related research.4,10–15 None, however, has explicitly reviewed the ‘functional cure’ concept.
Altruism: Scoping review of the literature and future directions for HIV cure-related research
2020, Journal of Virus EradicationCitation Excerpt :Table 1 summarizes lessons learned on altruism from our scoping review. Themes explored have implications for future socio-behavioral sciences related to HIV cure and underpin the ethical framing of biomedical sciences regarding participants’ benefits and expectations.113 In particular, we have found that valuable lessons can be learned from the fields of cancer and HIV prevention and treatment research to inform how we assess and contextualize altruism in HIV cure-related research.
A landscape analysis of HIV cure-related clinical trials and observational studies in 2018
2019, Journal of Virus EradicationCitation Excerpt :The field of HIV research – biomedical prevention as well as treatment and cure – is quite complex and requires increased engagement and understanding from all invested parties: review boards [19], communities [20–23] and referring providers. The reported enrolment obstacles – and the high reports of noobstacles to enrolment – merit further discussion and collaboration between community and researchers, particularly in light of evolving conversations around the acceptability of ATIs and other invasive procedures in HIV cure research [24,25]. Because these small early-phase studies are not required to enrol diverse participants, it will be important for study teams to balance the need to enrol quickly and to meet stringent inclusion/exclusion criteria with the potential ramifications of not including any female participants.
Putting participants at the centre of HIV cure research
2019, The Lancet HIVCommunity engagement group model in basic and biomedical research: lessons learned from the BEAT-HIV Delaney Collaboratory towards an HIV-1 cure
2023, Research Involvement and Engagement