Cell Stem Cell
Volume 1, Issue 3, 13 September 2007, Pages 259-262
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Human-Animal Chimeras in Biomedical Research

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Chimeras are individuals with tissues derived from more than one zygote. Interspecific chimeras have tissues derived from different species. The biological consequences of human-animal chimeras have become an issue of ethical debate. Ironically, human-animal chimeras with human blood, neurons, germ cells, and other tissues have been generated for decades. This has facilitated human biological studies and therapeutic strategies for disease.

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