CommentaryThe biological basis for defining bi-parental or tri-parental origin of offspring from cytoplasmic and spindle transfer
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Cited by (22)
Ethics of mitochondrial gene replacement therapy
2023, Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies, Second EditionEthics of mitochondrial gene replacement therapy
2018, Clinical Ethics at the Crossroads of Genetic and Reproductive TechnologiesSetting the record straight
2016, Reproductive BioMedicine OnlineA limited survey-based uncontrolled follow-up study of children born after ooplasmic transplantation in a single centre
2016, Reproductive BioMedicine OnlineCitation Excerpt :Mitochondrial DNA, unlike nuclear DNA, does not determine phenotypic characteristics like eye colour, skin colour or height. As a third person (the egg donor), however, was involved in the assisted reproduction process, the popular press referred to these children as ‘three parent babies’, a provocative but inaccurate reference (Cohen and Alikani, 2013). The publication of the finding that two of the eight tested children retained some mtDNA from the egg donors generated further controversy and concern in the scientific community.
Cytoplasmic, rather than nuclear-DNA, insufficiencies as the major cause of poor competence of vitrified oocytes
2015, Reproductive BioMedicine OnlineCitation Excerpt :This is compatible with the crucial role of mammalian ooplasm to support fertilization and early embryonic development (Sirard, 2012). Recently, karyoplast exchange has been investigated as a salvage tool to overcome oocytes insufficiencies often resulting from ageing or inheritable mitochondrial problems (Cohen and Alikani, 2013). Given the indispensable crucial importance of oocyte cryopreservation in current and future repertories of assisted reproductive techniques, karyoplast transplantation may also have far-reaching clinical applications to rescue cytoplasmic insufficiencies of vitrified oocytes.
Potential impact of human mitochondrial replacement on global policy regarding germline gene modification
2014, Reproductive BioMedicine Online