Seminal contribution
First clinical uterus transplantation trial: a six-month report

https://doi.org/10.1016/j.fertnstert.2014.02.024Get rights and content
Under an Elsevier user license
open archive

Objective

To report the 6-month results of the first clinical uterus transplantation (UTx) trial. This type of transplantation may become a treatment of absolute uterine-factor infertility (AUFI).

Design

Prospective observational study.

Setting

University hospital.

Patient(s)

Nine AUFI women and their live uterine donors, the majority being mothers.

Intervention(s)

Live-donor UTx and low-dose induction immunosuppression.

Main Outcome Measure(s)

Data from preoperative investigations, surgery and follow-up for 6 months.

Result(s)

Durations of donor and recipient surgery ranged from 10 to 13 hours and from 4 to 6 hours, respectively. No immediate perioperative complications occurred in any of the recipients. After 6 months, seven uteri remained viable with regular menses. Mild rejection episodes occurred in four of these patients. These rejection episodes were effectively reversed by corticosteroid boluses. The two graft losses were because of acute bilateral thrombotic uterine artery occlusions and persistent intrauterine infection.

Conclusion(s)

The results demonstrate the feasibility of live-donor UTx with a low-dose immunosuppressive protocol.

Clinical trial registration number

NCT01844362.

Key Words

Infertility
human
transplantation
uterus

Cited by (0)

M.B. has nothing to disclose. L.J. has nothing to disclose. P.D.-K. has nothing to disclose. A.E. has nothing to disclose. J.M. has nothing to disclose. N.K. has nothing to disclose. C.D.-G. has nothing to disclose. A.H. has nothing to disclose. C.L. has nothing to disclose. J.M. has nothing to disclose. M.G. has nothing to disclose. K.G. has nothing to disclose. R.A. has nothing to disclose. S.E. has nothing to disclose. J.H. is a shareholder of Allenex and a board member of Absorber. A.T. has nothing to disclose. M.O. has nothing to disclose.

M.B. and L.J. should be considered similar in author order.

Supported by Jane and Dan Olsson Research Foundation.