Trends in Neurosciences
Fetal nigral transplantation as a therapy for Parkinson's disease
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Identifying the optimal developmental age of human pluripotent stem cell-derived midbrain dopaminergic progenitors for transplantation in a rodent model of Parkinson's disease
2022, Experimental NeurologyCitation Excerpt :Within these studies, despite >80% of cells showing appropriate regional specification at the time of transplantation, the overall proportion of ventral midbrain dopaminergic (vmDA) neurons within grafts remains low. Likely underpinning this is the poor survival of vmDA progenitors/neuroblasts during cell preparation and immediately after implantation, as has been reported for fetal tissue (Olanow et al., 1996; Castilho et al., 2000), as well as the inclusion of a low proportion of highly proliferative non-vmDA progenitors within the donor cells (de Luzy et al., 2019; de Luzy et al., 2021). Several studies using vmDA fetal tissue have demonstrated that the maturity of donor cells at the time of engraftment can have a significant impact on graft composition and functional outcomes.
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C.W. Olanow is at the Dept of Neurology, Mount Sinai School of Medicine, New York, NY, USA. J.H. Kordower is at the Dept of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian Medical Center, Chicago, IL, USA and T.B. Freeman is at the Dept of Neurosurgery and Pharmacology, University of South Florida, Tampa, FL, USA.