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Weight of financial reward in the decision by medical students and experienced healthy volunteers to participate in clinical trials

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Summary

The aim of this survey was twofold: to assess the willingness of medical students to volunteer for clinical trials and to evaluate the weight of the financial reward and other general details as seen by healthy volunteers who had already participated in clinical trials. A specific questionnaire was given to each group to be answered anonymously.

Among the medical students only 2.9% had already volunteered, 39.7% said that they would never participate, 24.7% would do it for scientific interest, 32.2% for scientific interest and financial reward, and 4.2% for the financial reward alone.

In experienced volunteers, financial reward was the main reason to participate (90%) followed by curiosity (6.3%). The financial reward actually received was considered adequate compensation for the time and discomfort by most of the volunteers (83.7%).

The information supplied by the research team and the arrangements made to treat any hazardous event were considered adequate (47.5%) or optimal (42.5%). Almost all the experienced volunteers (93.8%) answered positively when asked about participation in future studies.

The results show that financial reward is a very important reason for healthy volunteers to participate in clinical trials.

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References

  1. Butler JK (1978) Is it ethical to conduct volunteer studies within the pharmaceutical industry? Lancet I: 816–818

    Google Scholar 

  2. Cardon PV, Dommel FW, Trumble RR (1976) Injuries to research subjects. N Engl J Med 295: 650–654

    CAS  PubMed  Google Scholar 

  3. Chaput de Saintonge DM, Crane GJ, Rust ND, Karadia S, Whittam LR (1988) Modelling determinants of expected rewards in healthy volunteers. Pharmaceut Med 3: 45–54

    Google Scholar 

  4. Darragh A, Kenney M, Lambe R and Brick I (1986) Sudden death of a volunteer. Lancet II: 93–94

    Google Scholar 

  5. Demarez JP, Plat Y, Laborde P, Albin H (1988) Essai clinique et consentement éclairé. Acceptabilité chez le malade français hospitalisé. Therapie 43: 1–4

    CAS  PubMed  Google Scholar 

  6. Editorial (1986) Research on healthy volunteers. Lancet II: 900–901

  7. Epstein LC, Lasagna L (1969) Obtaining informed consent. Arch Intern Med 123: 682–688

    Article  CAS  PubMed  Google Scholar 

  8. Hassar M, Pocelinko R, Weintraub M, Nelson D, Thomas G, Lasagna L (1977) Free-living volunteer's motivations and attitudes toward pharmacologic studies in man. Clin Pharmacol Ther 21: 515–519

    CAS  PubMed  Google Scholar 

  9. Kolata GB (1980) The death of a research subject. Hasting Center Report 10: 5–6

    CAS  Google Scholar 

  10. Novak E, Seckman CE, Steward R (1977) Motivations for volunteering as research subjects. J Clin Pharmacol 17: 365–371

    CAS  PubMed  Google Scholar 

  11. Royal College of Physicians (1986) Research in healthy volunteers. J R Coll Physicians Lond 20: 243–257

    Google Scholar 

  12. Vere DW (1978) Testing new drugs — The human volunteer. J Med Ethics 4: 81–83

    CAS  PubMed  Google Scholar 

  13. Vere DW (1987) Research on healthy volunteeres — a report of the Royal College of Physicians. Br J Clin Pharmacol 23: 375–377

    CAS  PubMed  Google Scholar 

  14. Zarafonetis CJD, Riley PA, Williss III PW, Power LH, Werbelow J, Farhat L, Beckwith W, Marks BH (1978) Clinically significant adverse effects in a Phase 1 testing program. Clin Pharmacol Ther 24: 127–132

    CAS  PubMed  Google Scholar 

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Bigorra, J., Baños, J.E. Weight of financial reward in the decision by medical students and experienced healthy volunteers to participate in clinical trials. Eur J Clin Pharmacol 38, 443–446 (1990). https://doi.org/10.1007/BF02336681

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  • DOI: https://doi.org/10.1007/BF02336681

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