Potential ethical concerns about attempting fertility preservation surgery in prepubertal children
| Before/at time of surgery | In future |
| Delay to cancer treatment | Impact of surgery on future gonadal function |
| Family’s comprehension that process is largely unproven for prepubertal tissue | Ongoing cost to family of tissue storage |
| Decreased quality of tissue due to previous gonadotoxic therapy | Reseeding the original disease when tissue reimplanted |
| False hope about child’s chances of survival | Fate of tissue if child dies |
| Surgical and anaesthetic risks, sometimes increased by comorbidities | Pressure on patient to use tissue |
| Child’s discomfort/distress | False hope about likelihood of pregnancy |
| Degree of risk to fertility from treatment | Health of offspring conceived |