Table 1

Protocol for the Adrenal Insufficiency in Paediatric study

Intervention	Timing	Details	Notes
ACTH stimulation test	Within 26 h of admission	One sample of blood followed by a small intravenous dose of ACTH followed by another sample of blood	Blood taken from an already existing line (ie, no venipuncture required)
ACTH stimulation test	Within 26 h of admission		This test is often part of standard-of-care and may have been administered regardless of the study
Repeat ACTH stimulation test	24 h after first test	See above	Only performed if patient still in the PICU with appropriate lines for bloodwork.
Repeat ACTH stimulation test	24 h after first test	See above	Total amount of blood over 2 days is less than a teaspoon