PT - JOURNAL ARTICLE AU - Steel, Robert AU - Buchak, Lara AU - Eyal, Nir TI - Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines AID - 10.1136/medethics-2020-106501 DP - 2020 Dec 01 TA - Journal of Medical Ethics PG - 808--812 VI - 46 IP - 12 4099 - http://jme.bmj.com/content/46/12/808.short 4100 - http://jme.bmj.com/content/46/12/808.full SO - J Med Ethics2020 Dec 01; 46 AB - To counter the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some have proposed accelerating SARS-CoV-2 vaccine development through controlled human infection (or ‘challenge’) trials. These trials would involve the deliberate exposure of relatively few young, healthy volunteers to SARS-CoV-2. We defend this proposal against the charge that there is still too much uncertainty surrounding the risks of COVID-19 to responsibly run such a trial.