TY - JOUR T1 - Chromosomal microarray analysis in prenatal diagnosis: ethical considerations of the Belgian approach JF - Journal of Medical Ethics JO - J Med Ethics SP - 104 LP - 109 DO - 10.1136/medethics-2018-105186 VL - 46 IS - 2 AU - Joke Muys AU - Bettina Blaumeiser AU - Katrien Janssens AU - Patrick Loobuyck AU - Yves Jacquemyn Y1 - 2020/02/01 UR - http://jme.bmj.com/content/46/2/104.abstract N2 - Detection of genetic aberrations in prenatal samples, obtained through amniocentesis or chorion villus biopsy, is increasingly performed using chromosomal microarray (CMA), a technique that can uncover both aneuploidies and copy number variants throughout the genome. Despite the obvious benefits of CMA, the decision on implementing the technology is complicated by ethical issues concerning variant interpretation and reporting. In Belgium, uniform guidelines were composed and a shared database for prenatal CMA findings was established. This Belgian approach sparks discussion: it is evidence-based, prevents inconsistencies and avoids parental anxiety, but can be considered paternalistic. Here, we reflect on the cultural and moral bases of the Belgian reporting system of prenatally detected variants. ER -