@article {Koplin440, author = {Julian Koplin and Dominic Wilkinson}, title = {Moral uncertainty and the farming of human-pig chimeras}, volume = {45}, number = {7}, pages = {440--446}, year = {2019}, doi = {10.1136/medethics-2018-105227}, publisher = {Institute of Medical Ethics}, abstract = {It may soon be possible to generate human organs inside of human-pig chimeras via a process called interspecies blastocyst complementation. This paper discusses what arguably the central ethical concern is raised by this potential source of transplantable organs: that farming human-pig chimeras for their organs risks perpetrating a serious moral wrong because the moral status of human-pig chimeras is uncertain, and potentially significant. Those who raise this concern usually take it to be unique to the creation of chimeric animals with {\textquoteleft}humanised{\textquoteright} brains. In this paper, we show how that the same style of argument can be used to critique current uses of non-chimeric pigs in agriculture. This reveals an important tension between two common moral views: that farming human-pig chimeras for their organs is ethically concerning, and that farming non-chimeric pigs for food or research is ethically benign. At least one of these views stands in need of revision.}, issn = {0306-6800}, URL = {https://jme.bmj.com/content/45/7/440}, eprint = {https://jme.bmj.com/content/45/7/440.full.pdf}, journal = {Journal of Medical Ethics} }