RT Journal Article SR Electronic T1 Revealing the results of whole-genome sequencing and whole-exome sequencing in research and clinical investigations: some ethical issues JF Journal of Medical Ethics JO J Med Ethics FD BMJ Publishing Group Ltd and Institute of Medical Ethics SP 317 OP 321 DO 10.1136/medethics-2013-101996 VO 41 IS 4 A1 Nina Hallowell A1 Alison Hall A1 Corinna Alberg A1 Ron Zimmern YR 2015 UL http://jme.bmj.com/content/41/4/317.abstract AB The introduction of new sequencing technologies whole-genome sequencing (WGS) and whole-exome sequencing (WES) that are much less finely targeted than previous genetic tests has resulted in ethical debate about what should be done with clinically significant findings that may arise during the sequencing process. In this piece we argue that, in addition to whether the finding has been intentionally sought or arises incidentally, the ethical issues concerning what should be done with WES and WGS findings are also influenced by whether sequencing occurs in a clinical or research setting. We argue that decisions about the disclosure of WGS and WES findings generated in the clinical context are much less ethically contentious than decision making about the feedback of research results. We conclude by calling for greater transparency about the purpose of sample collection, more explicit protocols for transitioning between research and clinical contexts and patients and research participants to be warned of the potential for incidental findings to be generated, their potential significance and the actions that might be taken as a result.