RT Journal Article SR Electronic T1 A written consent five centuries ago JF Journal of Medical Ethics JO J Med Ethics FD BMJ Publishing Group Ltd and Institute of Medical Ethics SP 639 OP 639 DO 10.1136/jme.2010.037713 VO 36 IS 10 A1 Salih Selek YR 2010 UL http://jme.bmj.com/content/36/10/639.abstract AB The term informed consent does not have long historical roots. Until recent centuries, healthcare professionals were not held responsible for providing information to patients. The author reports a written consent from Anatolia dated almost five centuries ago. The contract was signed in 1539 in Gaziantep, Turkey (formerly known as Aintab, Ottoman Empire). The document, of course, differs from modern counterparts. It lacks details of interventions. The author believes this to be the first written consent in medical history. Further investigations of court registers should be made to ascertain the earliest date of their appearance.