@article {Holland230, author = {A J Holland and J Wong}, title = {Genetically determined obesity in Prader-Willi syndrome: the ethics and legality of treatment.}, volume = {25}, number = {3}, pages = {230--236}, year = {1999}, doi = {10.1136/jme.25.3.230}, publisher = {Institute of Medical Ethics}, abstract = {A central characteristic of people with Prader-Willi Syndrome (PWS) is an apparent insatiable appetite leading to severe overeating and the potential for marked obesity and associated serious health problems and premature death. This behaviour may be due to the effects of the genetic defect resulting from the chromosome 15 abnormalities associated with the syndrome. We examine the ethical and legal dilemmas that can arise in the care of people with PWS. A tension exists between a genetic deterministic perspective and that of individual choice. We conclude that the determination of the capacity of a person with PWS to make decisions about his/her eating behaviour and to control that behaviour is of particular importance in resolving this dilemma. If the person is found to lack capacity, the common law principles of acting in a person{\textquoteright}s "best interests" using the "least restrictive alternative" may be helpful. Allowing serious weight gain in the absence of careful consideration of these issues is an abdication of responsibility.}, issn = {0306-6800}, URL = {https://jme.bmj.com/content/25/3/230}, eprint = {https://jme.bmj.com/content/25/3/230.full.pdf}, journal = {Journal of Medical Ethics} }