%0 Journal Article %A A Herxheimer %T Clinical trials: two neglected ethical issues. %D 1993 %R 10.1136/jme.19.4.211 %J Journal of Medical Ethics %P 211-218 %V 19 %N 4 %X Ethical reasons are presented for requiring 1) that a proposal for a clinical trial should be accompanied by a thorough review of all previous trials that have examined the same and closely related questions, and 2) that a trial should be approved by a research ethics committee only if the investigator undertakes to register it in an appropriate register of clinical trials as soon as one exists. %U https://jme.bmj.com/content/medethics/19/4/211.full.pdf