TY - JOUR T1 - Clinical trials: two neglected ethical issues. JF - Journal of Medical Ethics JO - J Med Ethics SP - 211 LP - 218 DO - 10.1136/jme.19.4.211 VL - 19 IS - 4 AU - A Herxheimer Y1 - 1993/12/01 UR - http://jme.bmj.com/content/19/4/211.abstract N2 - Ethical reasons are presented for requiring 1) that a proposal for a clinical trial should be accompanied by a thorough review of all previous trials that have examined the same and closely related questions, and 2) that a trial should be approved by a research ethics committee only if the investigator undertakes to register it in an appropriate register of clinical trials as soon as one exists. ER -